Evidence map›Paper›PMID 42635900›Full record

SynthesisEuropean archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry2026

Non- and minimally invasive management of hypersensitivity in molar-incisor hypomineralisation (MIH) at home and in clinical practice: a systematic review.

I J Brusevold, N N Lygidakis, D Gillam, D J Manton, F Wong, N A Lygidakis

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

I J BrusevoldInstitute of Clinical Dentistry, University of Oslo, Oslo, Norway. i.j.brusevold@odont.uio.no.ORCID https://orcid.org/0000-0002-3362-3015
N N LygidakisPrivate Peadiatric Dental Clinic, Athens, Greece.
D GillamFaculty of Medicine and Dentistry, Queen Mary University of London, London, UK.
D J MantonDepartment of Dentistry Orthodontics, University Medical Center Groningen, Groningen, Netherlands.ORCID https://orcid.org/0000-0002-4570-0620
F WongFaculty of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID https://orcid.org/0000-0001-7681-3647
N A LygidakisPrivate Peadiatric Dental Clinic, Athens, Greece.ORCID https://orcid.org/0000-0002-6356-4001

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this systematic review was to search the literature to evaluate the effect of various minimally invasive treatments to relieve hypersensitivity in teeth affected by molar-incisor hypomineralisation (MIH).

methodsAn electronic search in the databases MEDLINE via PubMed, Cochrane Central, clinicaltrials.gov, SCOPUS and EMBASE was performed in September 2025. The PRISMA guidelines were followed.

resultsOf 320 potential articles, seven were included in the systematic review. All were RCTs investigating hypersensitivity reduction measured after application of a remineralising agent or a minimally invasive restorative approach. The agents tested were fluoride toothpaste, hydroxyapatite toothpaste, casein phosphopeptide-amorphous calcium phosphate nano-complexes (CPP-ACP) paste, photobiomodulation (PBM), silver diamine fluoride (SDF), fissure sealants with or without SDF and reinforced glass ionomer filling materials.

conclusionsAll tested treatments gave reduced hypersensitivity at follow-up compared to baseline mainly in molars with MIH. However, the evidence is limited due to the few included studies having risk of bias resulting from lack of blinding, small samples and lack of information for previous daily hygiene habits.

Indexed as

CPP–ACPHypersensitivityMIHMolar-incisor hypomineralisationSDFSealantsSilver diammine fluoride

Identifiers

PMID42635900

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.