Evidence map›Paper›PMID 42635820›Full record

SynthesisEuropean journal of clinical pharmacology2026

Pharmacological interventions targeting cognition and related clinical outcomes in vascular dementia: a systematic review and meta-analysis of randomized controlled trials.

Tianyu Cheng, Lin Zhang, Yizhou Zhang, Huazheng Liang, Junyan Wang, Gengzhen Chen, Yujia Huo

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European journal of clinical pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tianyu ChengThe School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Lin ZhangThe School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Yizhou ZhangState Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, SAR, China.
Huazheng LiangSuzhou Industrial Park Monash Research Institute of Science and Technology, Monash University, Suzhou, China.
Junyan WangCentre for Smart Process Engineering, Great Bay University, Dongguan, 523808, China.
Gengzhen ChenThe People's Hospital of Chenghai District, Shantou City, Guangdong Province, China. 13502938066@139.com.
Yujia HuoThe People's Hospital of Chenghai District, Shantou City, Guangdong Province, China. Hyj18210653976@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeRandomized evidence for pharmacological interventions in vascular dementia (VaD) is fragmented. We conducted a VaD-focused, scale-specific systematic review and meta-analysis.

methodsWe searched four databases for English-language parallel-group randomized controlled trials (1990-2025). Comparable placebo-controlled outcomes were pooled using random-effects meta-analysis; non-poolable outcomes were synthesized according to SWiM. Risk of bias and certainty were assessed with RoB 2 and GRADE.

resultsSixteen trials included 5,668 participants across trial cohorts; with one exception, all were published in 2012 or earlier. EGb 761

conclusionGalantamine and memantine showed small short-term cognitive effects; EGb 761

Indexed as

CognitionDementia, VascularNootropic AgentsCognitive EnhancementGalantamineHumansMemantineRandomized Controlled Trials as TopicGalantamineMemantineNootropic AgentsCognitive outcomesHerbal medicinal productsMeta-analysisPharmacological interventionsRandomized controlled trialsSystematic reviewVascular dementia

Identifiers

PMID42635820
PMCPMC13503495

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.