ArticleEuropean journal of nuclear medicine and molecular imaging2026
Outcomes of [
Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
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Abstract
purposeConcurrent enzalutamide may upregulate PSMA expression and enhance the efficacy of [
methodsWe retrospectively evaluated 208 mCRPC patients treated with [
resultsMedian OS was 20.0 months in the concurrent enzalutamide group versus 12.4 months in the no-ARPI group (log-rank p = 0.082). In multivariable Cox analysis, concurrent enzalutamide was not independently associated with OS (hazard ratio 1.15, 95% confidence interval 0.77-1.70; p = 0.493). This lack of independent association was confirmed in propensity-score adjusted analyses. PFS (7.1 vs. 6.1 months; p = 0.112), PSA50 response rates (57.5% vs. 47.1%; p = 0.130) and toxicity profiles were similar between groups.
conclusionConcurrent enzalutamide during PSMA-RLT was not independently associated with improved OS or PFS in our cohort. The combination did not result in increased toxicity. Prospective studies are needed to further clarify the role of concurrent enzalutamide in this setting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.