ArticleClinical research in cardiology : official journal of the German Cardiac Society2026
Late cardiac effects of anthracycline-based therapy in childhood cancer survivors: a CMR study of cardiac strain and function.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Anthracycline-based therapies cause cancer therapy-related cardiac dysfunction (CTRCD) in childhood cancer survivors (CCS). This cross-sectional observational study aimed to assess the potential of cardiac strain, evaluated with cardiovascular magnetic resonance feature tracking (CMR-FT), as a marker of subclinical CTRCD in CCS treated with anthracyclines. We prospectively included 117 CCS examined approximately 12 years after treatment and retrospectively selected 79 age- and sex-matched controls. Cardiac strain was assessed with CMR-FT, including global longitudinal strain (GLS), global circumferential strain (GCS), global radial strain (GRS) for both ventricles, and longitudinal strain for both atria. CCS were further divided into CCS-low (< 250 mg/m
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