ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2026
Peak bone mass development in U.S. females with varied physical activity patterns: a longitudinal view using three maturational clocks.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Biological timing of peak bone mass is poorly characterized. Using whole body bone mass growth curves from childhood into adulthood, we show peak bone mass is reached 7 years after peak height velocity, 6 years post-menarche, and 19 years after birth. Early post-menarcheal screening would provide a window for intervention. PURPOSE: We evaluated bone mass growth curves for individuals representing diverse physical activity patterns from childhood into adulthood. We used three age clocks centered on birth (chronological age, CHRON
methodsWhole-body bone mineral content (WBBMC, g) was measured annually by DXA, with semi-annual stature measurements, in young females with heterogeneous musculoskeletal loading patterns. Data included participants with known menarche dates and ≥ 3 serial measures (CHRON
resultsData were modeled for 137 females, median 11 scans per individual (IQR (7,12); range 3-17; total 1343 scans). Mean ages (years) at PHV and menarche were 11.9 (SD 0.9) and 13.2 (SD 1.3), respectively. Mean ages at PKVBMC and PBM were CHRON
conclusionOn average, females reached PBM by CHRON
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