Evidence map›Paper›PMID 42635626›Full record

ArticleJournal of neuroimaging : official journal of the American Society of Neuroimaging

Association of Early M2 Pulsatility Index Ratio With Outcomes After Successful Endovascular Thrombectomy.

Seyed Behnam Jazayeri, Cattien Phan, Yasaman Pirahanchi, Ben Shifflett, Amirmohammad Eghbalnejadmofrad, Marissa D'Souza, Tiffany Hu, Sanad Batarseh, Behnam Sabayan, Jeffrey Steinberg and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroimaging : official journal of the American Society of Neuroimaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Association of Early M2 Pulsatility Index Ratio With Outcomes After Successful Endovascular Thrombectomy.Journal of neuroimaging : official journal of the American Society of Neuroimaging
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Seyed Behnam JazayeriDepartment of Neurosciences, Comprehensive Stroke Center, University of California, San Diego, California, USA.
Cattien PhanDepartment of Neurosciences, Comprehensive Stroke Center, University of California, San Diego, California, USA.
Yasaman PirahanchiDepartment of Neurosciences, Comprehensive Stroke Center, University of California, San Diego, California, USA.
Ben ShifflettDepartment of Neurosciences, Comprehensive Stroke Center, University of California, San Diego, California, USA.
Amirmohammad EghbalnejadmofradDepartment of Neurology, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Marissa D'SouzaDepartment of Neurosciences, Comprehensive Stroke Center, University of California, San Diego, California, USA.
Tiffany HuDepartment of Neurosciences, Comprehensive Stroke Center, University of California, San Diego, California, USA.
Sanad BatarsehDepartment of Neurosciences, Comprehensive Stroke Center, University of California, San Diego, California, USA.
Behnam SabayanDepartment of Neurology, Hennepin Healthcare Research Institute, Minneapolis, Minnesota, USA.
Jeffrey SteinbergDepartment of Neurosciences, Comprehensive Stroke Center, University of California, San Diego, California, USA.
Jeffrey S PannellDepartment of Neurosciences, Comprehensive Stroke Center, University of California, San Diego, California, USA.
David Santiago-DieppaDepartment of Neurosciences, Comprehensive Stroke Center, University of California, San Diego, California, USA.
Navaz P KaranjiaDepartment of Neurosciences, Comprehensive Stroke Center, University of California, San Diego, California, USA.
Jamie LaBuzettaDepartment of Neurosciences, Comprehensive Stroke Center, University of California, San Diego, California, USA.
Brian LemkuilDepartment of Neurosciences, Comprehensive Stroke Center, University of California, San Diego, California, USA.
Arthur LamDepartment of Neurosciences, Comprehensive Stroke Center, University of California, San Diego, California, USA.
Martin KrauseDepartment of Neurosciences, Comprehensive Stroke Center, University of California, San Diego, California, USA.
Anushirvan MinokadehDepartment of Neurosciences, Comprehensive Stroke Center, University of California, San Diego, California, USA.
Ali MahtaDepartment of Neurosciences, Comprehensive Stroke Center, University of California, San Diego, California, USA.
Theresa McQuaidDepartment of Neurosciences, Comprehensive Stroke Center, University of California, San Diego, California, USA.
Karen RappDepartment of Neurosciences, Comprehensive Stroke Center, University of California, San Diego, California, USA.
Kunal AgrawalDepartment of Neurosciences, Comprehensive Stroke Center, University of California, San Diego, California, USA.
Royya F ModirDepartment of Neurosciences, Comprehensive Stroke Center, University of California, San Diego, California, USA.
Thomas M HemmenDepartment of Neurosciences, Comprehensive Stroke Center, University of California, San Diego, California, USA.
Dawn M MeyerDepartment of Neurosciences, Comprehensive Stroke Center, University of California, San Diego, California, USA.
Alexander A KhalessiDepartment of Neurosciences, Comprehensive Stroke Center, University of California, San Diego, California, USA.
Brett C MeyerDepartment of Neurosciences, Comprehensive Stroke Center, University of California, San Diego, California, USA.
Reza Bavarsad ShahripourDepartment of Neurosciences, Comprehensive Stroke Center, University of California, San Diego, California, USA.

Funding

NIH HHS
6 · The paper itself

Abstract

background and purposeWe investigated whether early transcranial Doppler (TCD) ultrasound asymmetry indices could serve as bedside predictors of hemorrhagic transformation (HT) and 90-day outcome after successful endovascular thrombectomy (EVT).

methodsPatients with successful reperfusion (thrombolysis in cerebral infarction [TICI] ≥2b) after M1-segment EVT who underwent bilateral TCD within 8 h post-EVT were included. Ipsilateral-to-contralateral ratios for mean flow velocity (MFV) and pulsatility index (PI) were calculated for M1 (segment of the middle cerebral artery) and M2 (segment of the middle cerebral artery) segments. Multivariate logistic regression identified independent predictors of HT and poor 90-day outcome.

resultsAmong seventy patients (mean age 69.9 ± 6.7 years; 58.5% male), TCD was performed 5.3 ± 1.6 h after EVT. HT occurred in 45 patients (64.2%). Independent predictors of HT were younger age (p = 0.012), higher baseline NIHSS (p = 0.025), lower M2 PI ratio (p < 0.0001), and higher M2 MFV ratio (p = 0.010). Parenchymatous hemorrhage was predicted only by lower M2 PI ratio (p < 0.001). Poor 90-day outcome occurred in 35.7% and was associated with older age (p = 0.027), atrial fibrillation (p = 0.002), lower M2 PI ratio (p = 0.004), and higher M1 MFV ratio (p = 0.043). An M2 PI ratio ≤0.79 was associated with poor 90-day outcome with 89% specificity and 80% sensitivity (area under the curve [AUC] 0.91).

conclusionsEarly M2 PI ratio was associated with PH-type HT and poor 90-day outcome; however, given the small sample size, wide confidence intervals, and lack of external validation, these findings remain hypothesis-generating rather than ready-to-use prognostic tools. Larger studies are needed to confirm these preliminary observations.

Indexed as

Endovascular ProceduresMiddle Cerebral ArteryThrombectomyUltrasonography, Doppler, TranscranialAgedBlood Flow VelocityFemaleHumansMalePulsatile FlowReproducibility of ResultsSensitivity and SpecificityTreatment Outcomefunctional outcomehemorrhagic transformationlarge‐vessel occlusionstroketranscranial Doppler

Identifiers

PMID42635626
PMCPMC13502214

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.