Evidence map›Paper›PMID 42635610›Full record

ArticleCurrent protocols2026

Assessment of Natural Killer Cell Serial Degranulation.

Jens A Niemann, Carsten Watzl

Abstract read
In one paragraph

Article in Current protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jens A NiemannDepartment of Immunology, Leibniz Research Centre for Working Environment and Human Factors (IfADo), Dortmund, Germany.ORCID https://orcid.org/0009-0001-4866-4653
Carsten WatzlDepartment of Immunology, Leibniz Research Centre for Working Environment and Human Factors (IfADo), Dortmund, Germany.ORCID https://orcid.org/0000-0001-5195-0995

Funding

Leibniz Research Centre for Working Environment and Human Factors
6 · The paper itself

Abstract

Natural killer (NK) cells have been shown to be heterogeneous and to differ in their ability to kill target cells: although some NK cells show little cytotoxic activity, others sequentially kill multiple targets. The latter are called serial killers, and they perform this activity mainly via the release of cytotoxic granules. During this degranulation process, CD107a is exposed at the NK cell's surface. By staining this extracellular CD107a in a sequential manner, the ability of NK cells to serially degranulate while in co-culture with target cells can be analyzed. Here we describe a protocol for the detection and characterization of serial degranulating human NK cells. © 2026 The Author(s). Current Protocols published by Wiley Periodicals LLC. Basic Protocol: Natural killer cell serial degranulation assay.

Indexed as

Cell DegranulationKiller Cells, NaturalCoculture TechniquesHumansLysosomal-Associated Membrane Protein 1Lysosomal-Associated Membrane Protein 1cytotoxicitydegranulationnatural killer cellsserial killing

Identifiers

PMID42635610
PMCPMC13502215

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.