Evidence map›Paper›PMID 42635493›Full record

ArticleIndian journal of ophthalmology2026

Outcomes of higher-order aberration correction in relation to optical zone size after Phorcides-planned laser in situ keratomileusis in Indian Eyes.

Tanvi Haldipurkar, Mayuri Phatak, Seema Bhosale, Suhas Haldipurkar, Hetal Shah, Sarita Deshpande, Sabyasachi Sengupta

Abstract read
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Article in Indian journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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7 authors.

Tanvi HaldipurkarDepartment of Cataract and Refractive Surgery, Laxmi Eye Hospital and Institute, Panvel, Maharashtra, India.
Mayuri PhatakDepartment of Cataract and Refractive Surgery, Laxmi Eye Hospital and Institute, Panvel, Maharashtra, India.
Seema BhosaleDepartment of Cataract and Refractive Surgery, Laxmi Eye Hospital and Institute, Panvel, Maharashtra, India.
Suhas HaldipurkarDepartment of Cataract and Refractive Surgery, Laxmi Eye Hospital and Institute, Panvel, Maharashtra, India.
Hetal ShahDepartment of Cataract and Refractive Surgery, Laxmi Eye Hospital and Institute, Panvel, Maharashtra, India.
Sarita DeshpandeDepartment of Cataract and Refractive Surgery, Laxmi Eye Hospital and Institute, Panvel, Maharashtra, India.
Sabyasachi SenguptaDepartment of Cataract and Refractive Surgery, Laxmi Eye Hospital and Institute, Panvel, Maharashtra, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the influence of additional ablation (Abl-max) on higher-order aberrations (HOAs), particularly corneal coma, following Phorcides-planned topography-guided laser in situ keratomileusis (LASIK) in an Indian population.

methodsWe analyzed 161 eyes of 83 patients undergoing Phorcides-planned topography-guided LASIK between June 2022 and June 2023. Assessments at baseline and 1, 3, and 6 months included distance visual acuity, manifest refraction, Pentacam tomography, and iTrace aberrometry. Abl-Max was stratified into quartiles (Q1-4) and deciles (Q1-10). The primary outcomes were total HOAs and corneal coma (KCm) at 6 months. Logistic, linear, and decision tree regression models identified predictors of low coma (lowest quartile of KCm6 ≤ 0.037m).

resultsQ1 of Abl-max eyes had higher baseline myopia (-4.36 ± 1.62D vs. -2.76 ± 1.79D), and fewer were treated with 6.5 mm Optic Zone (OZ) (31.2% vs. 67.6%) compared to Q4 (both P < 0.001). At 6 months, KCm6 was higher in Q1 (0.11 ± 0.10 vs. 0.07 ± 0.06 µm in Q4, P = 0.015). The mean postoperative binocular uncorrected vision was 20/17 in both quartiles. Logistic regression showed that lower myopia (OR 1.51, 95% CI 1.21-1.92; P = 0.0004) and 6.5 mm OZ (OR 4.24, 95% CI 0.92-20.38; P = 0.066) predicted low coma. A decision tree model achieved AUROC 0.77, with the lowest coma in eyes with mild-moderate myopia (-2D to -3D) and 6.5 mm OZ.

conclusionPhorcides-planned LASIK permits safe deeper ablations with excellent vision, but coma induction persists, especially in higher myopes (>-4D) with 6.0 mm OZ. Larger OZs (6.5 mm) may optimize coma outcomes where residual stromal thickness permits.

Indexed as

Corneal Wavefront AberrationKeratomileusis, Laser In SituLasers, ExcimerMyopiaRefraction, OcularVisual AcuityAdultCorneal TopographyFemaleFollow-Up StudiesHumansIndiaMaleRetrospective StudiesTreatment OutcomeYoung AdultAblation maximumcomaLASIKoptical zone sizePhorcides

Identifiers

PMID42635493
PMCPMC13674926

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.