Evidence map›Paper›PMID 42635483›Full record

Trial reportTranslational vision science & technology2026

Use of a Retinal Phantom to Facilitate Adaptive Optics Scanning Light Ophthalmoscopy Imaging in a Multicenter Clinical Trial.

Joseph Kreis, Jessica Wong, Yushan Yang, Palash Bharadwaj, Robert F Cooper, Mina Gaffney, Nivedhitha Govindasamy, Amy L Green, Brian P Higgins, Yu You Jiang and 21 more

Registry-linked trialAbstract readMulticenter StudyClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Translational vision science & technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05537220 (NAC Attack, A Phase III, Multicenter, Randomized, Parallel, Double Masked, Placebo-Controlled Study Evaluating the Efficacy and Safety of Oral N-Acetylcysteine in Patients With Retinitis Pigmentosa), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05537220 phase3active not recruitingnot on this map

NAC Attack, A Phase III, Multicenter, Randomized, Parallel, Double Masked, Placebo-Controlled Study Evaluating the Efficacy and Safety of Oral N-Acetylcysteine in Patients With Retinitis Pigmentosa

TypeinterventionalSponsorJohns Hopkins UniversityRan2023 to 2030Enrolled485ConditionsRetinitis PigmentosaArmsN-acetylcysteine, Placebo
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Joseph KreisDepartment of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.
Jessica WongDepartment of Ophthalmology, University of California, San Francisco, San Francisco, CA, USA.
Yushan YangDivision of Biostatistics, Data Science Institute, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Palash BharadwajDepartment of Ophthalmology, University of Washington School of Medicine, Seattle, WA, USA.
Robert F CooperJoint Department of Biomedical Engineering, Marquette University and Medical College of Wisconsin, Milwaukee, WI, USA.
Mina GaffneyJoint Department of Biomedical Engineering, Marquette University and Medical College of Wisconsin, Milwaukee, WI, USA.
Nivedhitha GovindasamyBioengineering Graduate Group, University of Pennsylvania, Philadelphia, PA, USA.
Amy L GreenUCL Institute of Ophthalmology, University College London, London, UK.
Brian P HigginsDepartment of Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, WI, USA.
Yu You JiangScheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Angelos KalitzeosUCL Institute of Ophthalmology, University College London, London, UK.
Michel MichaelidesUCL Institute of Ophthalmology, University College London, London, UK.
Jessica I W MorganScheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jason PorterCollege of Optometry, University of Houston, Houston, TX, USA.
Jeremy D RogersDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Ian RosenthalDivision of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD, USA.
Ramkumar SabesanDepartment of Ophthalmology, University of Washington School of Medicine, Seattle, WA, USA.
Kaitlyn A SapoznikCollege of Optometry, University of Houston, Houston, TX, USA.
Alexander W SchillCollege of Optometry, University of Houston, Houston, TX, USA.
Ryan D SocholDepartment of Mechanical Engineering, University of Maryland, College Park, MD, USA.
Yiyi WangDepartment of Ophthalmology, University of California, San Francisco, San Francisco, CA, USA.
Raymond L WarnerScheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Emma WarrDepartment of Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, WI, USA.
Benjamin J WendelDepartment of Ophthalmology, University of Washington School of Medicine, Seattle, WA, USA.
Niamh WynneDepartment of Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, WI, USA.
Peiluo XuBioengineering Graduate Group, University of Pennsylvania, Philadelphia, PA, USA.
Sergey TarimaDivision of Biostatistics, Data Science Institute, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Daniel X HammerDivision of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD, USA.
Anant AgrawalDivision of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD, USA.
Jacque L DuncanDepartment of Ophthalmology, University of California, San Francisco, San Francisco, CA, USA.
Joseph CarrollDepartment of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.

Funding

Scientific TransparencyP30EY001583 · NEI · UNIVERSITY OF PENNSYLVANIA · PI CLAIRE H MITCHELL · 1985 to 2026
$19.5M
NAC Attack, a phase-3, multicenter, randomized, placebo-controlled trial in patients with retinitis pigmentosaUG1EY033293 · NEI · JOHNS HOPKINS UNIVERSITY · PI Xiangrong Kong · 2022 to 2026
$18.1M
Rapid-Prototyping and Design CoreP30EY002162 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ULLIAN, ERIK M · 1985 to 2024
$16.8M
Research Programming ModuleP30EY007551 · NEI · UNIVERSITY OF HOUSTON · PI Nimesh Bhikhu Patel · 1988 to 2026
$16.4M
Advanced Technology to Study Visual Function on a Cellular ScaleR01EY023591 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI DUNCAN, JACQUE LYNNE, ROORDA, AUSTIN · 2014 to 2023
$11.2M
Assessing Photoreceptor Structure and Function in Normal and Diseased RetinaeR01EY017607 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI Joseph Carroll · 2008 to 2026
$8.3M
Rresearch Training Program in Vision ScienceT32EY014537 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI Elena V Semina · 2002 to 2026
$4.2M
Retinal structure, function and response to gene therapyR01EY028601 · NEI · UNIVERSITY OF PENNSYLVANIA · PI Jessica I.W. Morgan · 2018 to 2026
$3.6M
Interferometric Optophysiology of the Human RetinaU01EY025501 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI ROORDA, AUSTIN · 2015 to 2019
$3.4M
Photoreceptor mosaic in health and diseaseR01EY029710 · NEI · UNIVERSITY OF WASHINGTON · PI Ramkumar Sabesan · 2019 to 2026
$2.9M
CTSA K12 Program at Baylor College of Medicine and University of HoustonK12TR004522 · NCATS · BAYLOR COLLEGE OF MEDICINE · PI Marino A Bruce, ELENA L GRIGORENKO · 2024 to 2026
$2.6M
NAC Attack AOSLO Reading CenterUG1EY033292 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph Carroll, JACQUE LYNNE DUNCAN · 2022 to 2026
$915k
NCATS NIH HHS K12 TR004522NEI NIH HHS F31 EY036692NEI NIH HHS F31 EY036709NEI NIH HHS P30 EY001583NEI NIH HHS P30 EY002162NEI NIH HHS P30 EY007551NEI NIH HHS R01 EY017607NEI NIH HHS R01 EY023591NEI NIH HHS R01 EY028601NEI NIH HHS R01 EY029710NEI NIH HHS T32 EY014537NEI NIH HHS U01 EY025501NEI NIH HHS UG1 EY033292NEI NIH HHS UG1 EY033293
6 · The paper itself

Abstract

Purpose: To describe the use of a model eye-mounted retinal phantom to support adaptive optics scanning light ophthalmoscope (AOSLO) imaging in a multicenter clinical trial (NCT05537220). Methods: Six three-dimensional-printed retinal phantoms were mounted in model eyes. These phantoms contain equally spaced arrays of reflective "cone-like" structures mimicking foveal cone photoreceptor spacing. Intrasession repeatability of phantom imaging was assessed for all six phantoms on two custom AOSLOs. One phantom was also imaged on two additional AOSLOs to assess interdevice reproducibility. Lastly, each of the six phantoms was imaged longitudinally at their respective trial sites. Results: Intrasession repeatability of phantom-derived horizontal "cone" spacing measures was high for two different AOSLOs. However, intersystem differences were found in the average horizontal "cone" spacing of five of eight patches assessed. Across four unique AOSLOs, intersystem differences were found in the average horizontal "cone" spacing of seven of eight patches assessed. A linear regression analysis of longitudinal phantom imaging with a single AOSLO revealed few significant changes in horizontal "cone" spacing over the course of about 2 years. Similar results were observed for vertical "cone" spacing measures across the three experiments. Conclusions: Longitudinal spacing measurements were generally stable in our study. However, small but significant differences in spacing were observed between systems. The approach described here may facilitate combining cone metrics extracted from images acquired using different AOSLOs in multicenter studies. Translational Relevance: Cross-system validation strategies can support the use of AOSLO imaging in multicenter clinical trials.

Indexed as

OphthalmoscopesOptics and PhotonicsPhantoms, ImagingRetinaHumansOphthalmoscopyReproducibility of ResultsRetinal Cone Photoreceptor Cells

Identifiers

PMID42635483
PMCPMC13543627

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.