ArticleTranslational vision science & technology2026
Associations Between Choroidal Structural Parameters and Cone Photoreceptors in Young High Myopia.
Article in Translational vision science & technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To evaluate the association between choroidal structural parameters and cone photoreceptor characteristics in young individuals with different degrees of myopia and to assess whether choroidal thickness (CT) may indicate early photoreceptor alterations in high myopia (HM). Methods: Ninety-three participants aged 18 to 28 years were classified as nonmyopic, mildly to moderately myopic, or highly myopic. CT and choroidal vascularity index (CVI) were measured using swept-source optical coherence tomography angiography. Cone metrics were quantified using adaptive optics scanning laser ophthalmoscopy with automated segmentation. Cone measurements were averaged across sampling locations to derive an overall value per eye. Group comparisons and associations were analyzed using appropriate parametric or nonparametric tests, correlation analysis, and multivariable linear regression. Results: CT decreased progressively with increasing myopia across all macular regions (P < 0.001), while CVI showed no significant differences. Cone density was reduced in HM, with increased spacing and reduced regularity (P < 0.001). In unadjusted analyses, cone density was positively associated with CT (r = 0.313 to 0.394, P < 0.01). Each 1-µm increase in CT corresponded to an increase of approximately 10 to 12 cells/mm² in cone density. Conclusions: Young HM eyes show concurrent reductions in CT and cone integrity, while CVI remains relatively stable. The observed associations likely reflect shared structural changes related to axial elongation rather than independent effects of CT. Translational Relevance: CT may serve as a practical structural biomarker for early retinal alterations in HM.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.