Evidence map›Paper›PMID 42635432›Full record

ArticlemSphere2026

Cysteine import contributes to hypochlorous acid resistance in

Abigail G Hall, Aliyah J Collins, Anna Sommers, Ryan Singh, Sasmita Panda, Sujata S Chaudhari, Andrew J Monteith, Vinai C Thomas

Abstract read
In one paragraph

Article in mSphere, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Abigail G HallDepartment of Pathology, Microbiology and Immunology, Center for Staphylococcal Research, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Aliyah J CollinsDepartment of Microbiology, University of Tennessee, Knoxville, Tennessee, USA.
Anna SommersDepartment of Pathology, Microbiology and Immunology, Center for Staphylococcal Research, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Ryan SinghDepartment of Pathology, Microbiology and Immunology, Center for Staphylococcal Research, University of Nebraska Medical Center, Omaha, Nebraska, USA.ORCID 0000-0001-9711-1951
Sasmita PandaDepartment of Pathology, Microbiology and Immunology, Center for Staphylococcal Research, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Sujata S ChaudhariDepartment of Pathology, Microbiology and Immunology, Center for Staphylococcal Research, University of Nebraska Medical Center, Omaha, Nebraska, USA.ORCID 0000-0002-9609-152X
Andrew J MonteithDepartment of Microbiology, University of Tennessee, Knoxville, Tennessee, USA.ORCID 0000-0002-7259-6574
Vinai C ThomasDepartment of Pathology, Microbiology and Immunology, Center for Staphylococcal Research, University of Nebraska Medical Center, Omaha, Nebraska, USA.ORCID 0000-0002-7886-0727

Funding

The S. aureus biofilm lifecycleP01AI083211 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KIELIAN, TAMMY L · 2009 to 2023
$32.1M
The role of arginine catabolic pathways in modulating staphylococcal fitnessR01AI125588 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI THOMAS, VINAI · 2018 to 2022
$1.9M
Defining the mitochondrial metabolic regulation of systemic innate inflammationR35GM154838 · NIGMS · UNIVERSITY OF TENNESSEE KNOXVILLE · PI Andrew J Monteith · 2024 to 2026
$1.1M
Fundamental Training Program in Biochemistry and Molecular Biology ResearchT32GM153375 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Steven H Caplan, Ricia Katherine Hyde · 2024 to 2026
$949k
Staphylococcus aureus metabolic requirements during skin colonizationR01AI192812 · NIAID · UNIVERSITY OF COLORADO DENVER · PI ALEXANDER R HORSWILL · 2026 to 2026
$740k
American Heart Association 25PRE1369371National Institute of Allergy and Infectious Diseases P01AI083211National Institute of Allergy and Infectious Diseases R01AI125588National Institute of Allergy and Infectious Diseases R01AI192812NIAID NIH HHS P01 AI083211NIAID NIH HHS R01 AI125588NIAID NIH HHS R01 AI192812NIGMS NIH HHS 1R35GM154838NIGMS NIH HHS 1T32GM153375-01NIGMS NIH HHS R35 GM154838NIGMS NIH HHS T32 GM153375
6 · The paper itself

Abstract

Hypochlorous acid (HOCl) is a potent antimicrobial oxidant produced by innate immune cells to eliminate invading bacterial pathogens, including

Indexed as

CysteineDrug Resistance, BacterialHypochlorous AcidStaphylococcus aureusBacterial ProteinsGlucosamineHumansMicrobial ViabilityNeutrophilsOxidative StressSulfhydryl CompoundsbacillithiolBacterial ProteinsCysteineGlucosamineHypochlorous AcidSulfhydryl CompoundsbacillithiolhypochloriteL-cysteineL-cystineStaphylococcus aureusstress

Identifiers

PMID42635432
PMCPMC13621853

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.