Evidence map›Paper›PMID 42635419›Full record

ArticleMicrobiology spectrum2026

Adrien Turban, Benjamin Quenet, Charlotte Michaux, François Guérin, Vincent Cattoir

Abstract read
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Adrien TurbanDepartment of Bacteriology, University Hospital of Rennes, Rennes, France.ORCID 0000-0001-7577-0059
Benjamin QuenetInserm U1230 Bacterial RNAs and Medicine, University of Rennes, Rennes, France.ORCID 0009-0002-7932-7702
Charlotte MichauxInserm U1230 Bacterial RNAs and Medicine, University of Rennes, Rennes, France.ORCID 0000-0003-1089-7846
François GuérinDepartment of Bacteriology, University Hospital of Rennes, Rennes, France.ORCID 0000-0001-6821-3131
Vincent CattoirDepartment of Bacteriology, University Hospital of Rennes, Rennes, France.ORCID 0000-0003-4026-9912

Funding

Institut National de la Santé et de la Recherche MédicaleSanté publique FranceUniversité de Rennes
6 · The paper itself

Abstract

Delafloxacin (DLX) is a novel fluoroquinolone (FQ) with enhanced activity against gram-positive bacteria and under acidic conditions. Since the pH of urine is usually acidic, DLX could be an alternative to current drugs for urinary tract infections (UTIs), especially in male patients, for whom good prostatic tissue penetration is required. The aim of this study was to evaluate IMPORTANCE: Enterococci urinary tract infections (UTIs) are common but often difficult to treat in male patients, in whom good prostatic tissue penetration is required. Fluoroquinolones (FQs) remain attractive in this setting even though their efficacy is altered by the acidic pH of urine. Delafloxacin (DLX) is a novel FQ whose structure confers enhanced activity against gram-positive bacteria and under acidic conditions such as urine. Here, we demonstrate that DLX is substantially more active

Indexed as

Anti-Bacterial AgentsDrug Resistance, BacterialEnterococcus faecalisEnterococcus faeciumFluoroquinolonesGram-Positive Bacterial InfectionsUrinary Tract InfectionsHumansLevofloxacinMaleMicrobial Sensitivity TestsAnti-Bacterial AgentsdelafloxacinFluoroquinolonesLevofloxacindelafloxacinE. faecalisfluoroquinolonesUTI

Identifiers

PMID42635419
PMCPMC13689276

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.