Evidence map›Paper›PMID 42635357›Full record

ArticleEuropean journal of immunology2026

Single-Cell Profiling Identifies Skin-Resident Memory CD4

Jonah Clegg, Giovanni Cova, Alberto Carignano, Megan Smith, Emiliano Chiarot, Simona Tavarini, Chiara Sammicheli, Nicholas Rachmaninoff, Serena Vastola, Silvia Guidotti and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Single-Cell Profiling Identifies Skin-Resident Memory CD4European journal of immunology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jonah CleggGSK, via Fiorentina 1, Siena, Italy.
Giovanni CovaGSK, via Fiorentina 1, Siena, Italy.
Alberto CarignanoGSK, via Fiorentina 1, Siena, Italy.
Megan SmithGSK, via Fiorentina 1, Siena, Italy.
Emiliano ChiarotGSK, via Fiorentina 1, Siena, Italy.
Simona TavariniGSK, via Fiorentina 1, Siena, Italy.
Chiara SammicheliGSK, via Fiorentina 1, Siena, Italy.
Nicholas RachmaninoffGSK, Rockville, Maryland, USA.
Serena VastolaGSK, via Fiorentina 1, Siena, Italy.
Silvia GuidottiGSK, via Fiorentina 1, Siena, Italy.
Emilio SienaGSK, via Fiorentina 1, Siena, Italy.
Monia BardelliGSK, via Fiorentina 1, Siena, Italy.
Fabio BagnoliGSK, via Fiorentina 1, Siena, Italy.
Michela BrazzoliGSK, via Fiorentina 1, Siena, Italy.
Rachel M McLoughlinHost Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Elisabetta SoldainiGSK, via Fiorentina 1, Siena, Italy.

Funding

Research Ireland Frontiers for the Future Award 23/FFP-A/12244Wellcome Discovery Award 338537/Z/25/ZWellcome Trust
6 · The paper itself

Abstract

Staphylococcus aureus is a leading cause of skin and soft tissue infections (SSTIs), yet the cellular mediators of protective memory remain incompletely defined. Using a self-resolving murine SSTI model, we combined longitudinal single-cell RNA sequencing with flow cytometry to characterize immune memory within the skin following infection. We identified a persistent population of CD4

Indexed as

CD4-Positive T-LymphocytesImmunologic MemoryMemory T CellsSkinStaphylococcal Skin InfectionsStaphylococcus aureusAnimalsFemaleMiceMice, Inbred C57BLSingle-Cell AnalysisS. aureusscRNA‐seqskin infectiontissue‐resident memory T cellsγδ T cells

Identifiers

PMID42635357
PMCPMC13501939

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.