Evidence map›Paper›PMID 42635328›Full record

ArticleClinical cardiology2026

Correlation Between the High-Sensitivity C-Reactive Protein-to-Albumin Ratio and All-Cause Mortality in Patients With Acute Exacerbation of Chronic Heart Failure.

Xi Gu, Jinli Feng, Pinye Chen, Hao Wang, Tao Rui, Junfang Guo

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Article in Clinical cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Xi GuDepartment of Cardiology, Jiangsu University Affiliated People's Hospital (Zhenjiang First People's Hospital), Zhenjiang, Jiangsu, China.ORCID https://orcid.org/0009-0003-7566-5517
Jinli FengDepartment of Cardiology, Jiangsu University Affiliated People's Hospital (Zhenjiang First People's Hospital), Zhenjiang, Jiangsu, China.
Pinye ChenDepartment of Cardiology, Jiangsu University Affiliated People's Hospital (Zhenjiang First People's Hospital), Zhenjiang, Jiangsu, China.ORCID https://orcid.org/0009-0009-1060-6288
Hao WangDepartment of Cardiology, Jiangsu University Affiliated People's Hospital (Zhenjiang First People's Hospital), Zhenjiang, Jiangsu, China.
Tao RuiDepartment of Cardiology, Jiangsu University Affiliated People's Hospital (Zhenjiang First People's Hospital), Zhenjiang, Jiangsu, China.
Junfang GuoDepartment of Cardiology, Jiangsu University Affiliated People's Hospital (Zhenjiang First People's Hospital), Zhenjiang, Jiangsu, China.

Funding

Zhenjiang Municipal Key Laboratory of Clinical Medicine for Myocardial Diseases SS2023010
6 · The paper itself

Abstract

objectiveTo evaluate the correlation between the high-sensitivity C-reactive protein-to-albumin ratio (CAR) and all-cause mortality in patients with acute exacerbation of chronic heart failure (AECHF).

methodsIn this retrospective cohort study, 342 patients were enrolled from the First People's Hospital of Zhenjiang City between January 1, 2020, and December 31, 2025. Cox regression analyses, subgroup analyses, Kaplan-Meier survival curves, and receiver operating characteristic (ROC) analyses were employed to assess the association between CAR and all-cause mortality.

resultsDuring a median follow-up period of 16.35 months, 95 patients (27.8%) died. Multivariate Cox regression analysis revealed that each unit increase and each standard deviation increase in CAR were associated with a 41.2% and 40.7% increased risk of all-cause mortality, respectively (HR: 1.412, 95% CI: 1.221-1.633; HR: 1.407, 95% CI: 1.219-1.625). The risk of all-cause mortality in the high CAR group was 1.778 times that of the low CAR group (HR: 1.778; 95% CI: 1.092-2.894). The robustness of the association between CAR and all-cause mortality was further corroborated by subgroup and sensitivity analyses (p < 0.05). Kaplan-Meier survival curves revealed significant survival differences across CAR subgroups, with markedly lower cumulative survival observed in the high-CAR group (p < 0.05). ROC curve indicated a weak but statistically significant predictive value for all-cause mortality risk (p = 0.025).

conclusionHigher levels of CAR are associated with a higher risk of all-cause mortality in AECHF patients.

Indexed as

C-Reactive ProteinHeart FailureSerum AlbuminSerum Albumin, HumanAgedBiomarkersCause of DeathChinaChronic DiseaseDisease ProgressionFemaleFollow-Up StudiesHumansMaleMiddle AgedPredictive Value of TestsBiomarkersC-Reactive ProteinSerum AlbuminSerum Albumin, Humanacute exacerbation of chronic heart failurealbuminall‐cause mortalityhigh‐sensitivity C‐reactive proteinhigh‐sensitivity C‐reactive protein to albumin ratio

Identifiers

PMID42635328
PMCPMC13501897

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.