ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026
Interleukin-19 Regulates Adipose Tissue Dysfunction in Obesity: Interplay Between Inflammation and Vascularization.
Christine N Vrakas, Tatsuo Kawai, Mitali Ray, Allison B Herman, Zeinab Etwebi, Sheri E Kelemen, Rosario Scalia, Michael V Autieri
Abstract read
In one paragraphArticle in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Christine N VrakasLemole Center for Lymphatic Research and Cardiovascular Sciences Department, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Tatsuo KawaiLemole Center for Lymphatic Research and Cardiovascular Sciences Department, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-0101-1054 Mitali RayLemole Center for Lymphatic Research and Cardiovascular Sciences Department, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Allison B HermanLemole Center for Lymphatic Research and Cardiovascular Sciences Department, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Zeinab EtwebiLemole Center for Lymphatic Research and Cardiovascular Sciences Department, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Sheri E KelemenLemole Center for Lymphatic Research and Cardiovascular Sciences Department, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Rosario ScaliaLemole Center for Lymphatic Research and Cardiovascular Sciences Department, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Michael V AutieriLemole Center for Lymphatic Research and Cardiovascular Sciences Department, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-1039-7577 Funding
miRNA-mediated reduction of VSMC foam cell formationR01HL117724 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI AUTIERI, MICHAEL V · 2013 to 2022
$3.8MAttenuation of atherosclerosis by regulation of VSMC inflammatory gene mRNA stabilityR01HL141108 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI AUTIERI, MICHAEL V · 2018 to 2021
$2.0MRegulation of adipose tissue microvascular function by IL19R01DK133747 · NIDDK · TEMPLE UNIV OF THE COMMONWEALTH · PI AUTIERI, MICHAEL V, SCALIA, ROSARIO G · 2022 to 2024
$1.6MHHS | National Institutes of Health (NIH) DK133747HHS | National Institutes of Health (NIH) HL117724HHS | National Institutes of Health (NIH) HL141108NHLBI NIH HHS R01 HL117724NHLBI NIH HHS R01 HL141108NIDDK NIH HHS R01 DK133747
6 · The paper itselfAbstract
Expanding visceral white adipose tissue (WAT) becomes hypoxic due to lack of compensatory vascularization. Hypoxia initiates inflammation, presumably to promote angiogenesis. Unfortunately, in obesity this results in adipocyte dysfunction and related cardiometabolic complications due to chronic low-grade inflammation. We hypothesize that IL-19 acts as a vascular and immunometabolic protective adipokine in obesity. We report that IL-19 is expressed in WAT. Utilizing lean Il19
Indexed as
Adipose TissueAdipose Tissue, WhiteAngiogenesisInflammationInterleukinsNeovascularization, PathologicObesityAdipocytesAnimalsGlucose IntoleranceHumansInsulin ResistanceMaleMiceMice, Inbred C57BLMice, KnockoutIl19 protein, mouseInterleukinsadipose tissueangiogenesisinflammationinterleukin‐19obesity
Identifiers
PMID42634927
PMCPMC13501345
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