Evidence map›Paper›PMID 42634913›Full record

ArticlePediatric pulmonology2026

Impact of Intermittent Positive Pressure Breathing on Thoracic Growth in Children With Type 1 Spinal Muscular Atrophy.

Charlotte Thébault, Sophie Denamur, Gilles Thomas, Audrey Barzic, Elsa Schwartz, Maëlle Dupuis, Marie-Christine Nougues, Arnaud Isapof, Guillaume Aubertin, Jessica Taytard

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric pulmonology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Charlotte ThébaultPediatric Physical Medicine and Functional Rehabilitation Department, AP-HP, Sorbonne Université, Hospital Armand Trousseau, Paris, France.ORCID https://orcid.org/0009-0007-3010-7860
Sophie DenamurSorbonne University, Inserm, Saint-Antoine Research Centre, CRSA, AP-HP, Hospital Armand Trousseau, Paediatric Pulmonology, Paris, France.
Gilles ThomasPediatric department, CHU Brest, Brest, France.
Audrey BarzicPediatric department, CHU Brest, Brest, France.
Elsa SchwartzPediatric Physical Medicine and Functional Rehabilitation Department, AP-HP, Sorbonne Université, Hospital Armand Trousseau, Paris, France.
Maëlle DupuisPediatric Physical Medicine and Functional Rehabilitation Department, AP-HP, Sorbonne Université, Hospital Armand Trousseau, Paris, France.
Marie-Christine NouguesPediatric Neurology Department, AP-HP, Sorbonne Université, Hospital Armand Trousseau, Paris, France.
Arnaud IsapofPediatric Neurology Department, AP-HP, Sorbonne Université, Hospital Armand Trousseau, Paris, France.
Guillaume AubertinSorbonne University, Inserm, Saint-Antoine Research Centre, CRSA, AP-HP, Hospital Armand Trousseau, Paediatric Pulmonology, Paris, France.ORCID https://orcid.org/0000-0001-5765-0555
Jessica TaytardPediatric Lung Function Testing and Sleep Unit, AP-HP, Sorbonne Université, Hospital Armand Trousseau, Paris, France.ORCID https://orcid.org/0000-0002-7552-3880

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe emergence of new disease-modifying treatments for type I spinal muscular atrophy (SMA I) has led to a paradigm shift in the respiratory management of these patients. Accompanying pulmonary and thoracic growth appears to be a key factor in their morbidity and mortality. The role of Intermittent Positive Pressure Breathing (IPPB) on thoracic growth has been described in the literature, but there are few studies available to objectively assess its impact. STUDY

objectiveTo assess the impact of using IPPB on thoracic growth in children with SMA I. MATERIAL/

methodIn this bicentric retrospective study, the thoracic circumference-to-head circumference ratio (TC/HC) was compared at three time points: 4 months before the initiation of IPPB, at the start of IPPB, and 4 months after initiation.

resultsSeven children (3 girls and 4 boys) with SMA I with a median (min-max) age of 4.8 (2.6-8.2) years old were included in this study. A statistically significant increase was observed in the mean change in TC/HC between the pre-IPPB and post-IPPB periods (-0.05 ± 0.03 vs. +0.06 ± 0.07, p = 0.04).

conclusionIn this study, IPPB was associated with a significant increase in TC/HC in children with SMA I. Further large-scale studies are warranted to better characterize the extent and clinical significance of this effect.

Indexed as

Intermittent Positive-Pressure VentilationSpinal Muscular Atrophies of ChildhoodThoraxChildChild, PreschoolFemaleHumansMaleRetrospective Studieschild developmentintermittent positive pressure breathingneuromuscular diseasesspinal muscular atrophythoracic wall

Identifiers

PMID42634913
PMCPMC13501201

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.