ArticleJournal of pain research2026
The ED90 of Liposomal Bupivacaine for Motor-Sparing After Interscalene Brachial Plexus Block: A Dose-Finding Study.
Article in Journal of pain research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Purpose: In adult arthroscopic rotator cuff repair, interscalene brachial plexus block using liposomal bupivacaine has been proven to effectively provide analgesic effects. However, concerns about motor-blocking may restrict its widespread clinical application. This study aimed to determine the 90% minimum effective dose (ED90) of liposomal bupivacaine for successful sensory blockade with motor-sparing following ultrasound-guided interscalene brachial plexus block. Patients and Methods: A total of 55 patients undergoing arthroscopic rotator cuff repair received an ultrasound-guided interscalene block using liposomal bupivacaine. The study employed an up-and-down sequential method with a biased-coin design. The primary outcome was the ED90 of liposomal bupivacaine in middle-aged patients undergoing motor-sparing (sensory score of 1 or 2 and a motor score of >2 during 3-72 hours after surgery) ultrasound-guided interscalene brachial plexus block. Secondary outcomes included Numerical Rating Scale (NRS) and numbness scores; as well as the percentage change in diaphragmatic excursion and pulse oxygen saturation (SpO Results: In total, 53 patients completed the study. The estimated ED90 of liposomal bupivacaine was 46.55 mg [90% confidence interval (CI), 39.36-48.41]. There was no significant difference observed in diaphragmatic excursion ( Conclusion: Motor-sparing ultrasound-guided interscalene brachial plexus block using liposome bupivacaine with a dose of 46.55 mg enables successful sensory blocks in 90% of middle-aged adults after excluding cases with failed sensory blockade.
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