ReviewMicrobiologyOpen2026
Unlocking the Bioactive Potential of Streptomyces: A Multidisciplinary Approach to Strain Improvement.
Review in MicrobiologyOpen, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptomyces is a genus of Gram-positive bacteria renowned for its remarkable ability to produce a diverse array of secondary metabolites (SMs), many of which possess significant pharmaceutical and agricultural value. Unlocking the full biopotential of Streptomyces is increasingly important in the quest for new therapeutics and sustainable solutions to global challenges, such as antibiotic resistance and food security. This review paper aims to bridge gaps in the literature by providing a comprehensive, integrative overview of recent advances in Streptomyces strain improvement. It discusses optimization of SM production in Streptomyces through a multidisciplinary approach. It also highlights the integration of traditional methods with modern genetic and metabolic engineering techniques to improve biosynthetic pathways, as well as adaptive laboratory evolution for strain development, systems, and fermentation, aiming to maximize the production of valuable bioactive compounds. While previous studies have explored individual aspects of strain optimization, this review presents a unified perspective on how these strategies can be applied effectively. This review not only enhances the understanding of Streptomyces biopotential but also addresses the need for a holistic framework that considers both established and emerging techniques in strain improvement. By filling these gaps, this review contributes to a more complete understanding of how to optimize Streptomyces for the production of valuable bioactive compounds, guiding future innovations and applications in biotechnology and pharmaceuticals.
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Registered trials
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