Evidence map›Paper›PMID 42634470›Full record

ArticleMolecular nutrition & food research2026

Phytoene, a Precursor of Lycopene in Tomatoes, Protects Against Metabolic Dysfunction-Associated Steatotic Liver Disease in Mice.

Na Youn Lee, Jennifer Lee, Nirupa R Matthan, Stefania Lamon-Fava, Xiang-Dong Wang

Abstract read
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Article in Molecular nutrition & food research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Na Youn LeeJean Mayer USDA Human Nutrition Research Center On Aging at Tufts University, Boston, Massachusetts, USA.
Jennifer LeeJean Mayer USDA Human Nutrition Research Center On Aging at Tufts University, Boston, Massachusetts, USA.
Nirupa R MatthanJean Mayer USDA Human Nutrition Research Center On Aging at Tufts University, Boston, Massachusetts, USA.
Stefania Lamon-FavaJean Mayer USDA Human Nutrition Research Center On Aging at Tufts University, Boston, Massachusetts, USA.
Xiang-Dong WangJean Mayer USDA Human Nutrition Research Center On Aging at Tufts University, Boston, Massachusetts, USA.

Funding

United States Department of Agriculture (USDA)/National Institute of Food and Agriculture AFRI 2023-67017-39760United States Department of Agriculture (USDA)/National Institute of Food and Agriculture AFRI 8050-10700-003-000D
6 · The paper itself

Abstract

The health benefits of tomato consumption may derive from bioactive compounds other than lycopene in tomatoes. 15-Cis-phytoene, a colorless precursor of lycopene abundant in tomatoes, has not been well studied for its biological activity. We investigated whether dietary 15-cis-phytoene protects against metabolic dysfunction-associated steatotic liver disease (MASLD) and whether this protection depends on the carotenoid cleavage enzymes, beta-carotene-15,15'-oxygenase 1 (BCO1) and beta-carotene-9',10'-oxygenase (BCO2). Wild-type (WT) and BCO1

Indexed as

CarotenoidsFatty LiverSolanum lycopersicumAnimalsbeta-Carotene 15,15'-MonooxygenaseDietary SupplementsDioxygenasesLiverLycopeneMaleMiceMice, Inbred C57BLMice, KnockoutPPAR alphaSirtuin 1(all-E) phytoeneBco1 protein, mouseBco2 protein, mousebeta-Carotene 15,15'-MonooxygenaseCarotenoidsDioxygenasesLycopenePPAR alphaPpara protein, mouseSirt1 protein, mouseSirtuin 1carotenoid cleavage enzymesfatty acid oxidationhigh‐refined carbohydrate dietmetabolic dysfunction‐associated steatotic liver diseasephytoene

Identifiers

PMID42634470
PMCPMC13501062

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.