BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid-derived suppressor cells.

Abstract read

In one paragraph

Article in FEBS open bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yingying ChenDepartment of Clinical Laboratory, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, China.ORCID https://orcid.org/0000-0002-1669-3003

Hui LiTianjin Institute of Immunology, Key Laboratory of Immune Microenvironment and Disease of the Ministry of Education, Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, China.

Funding

Guangzhou Municipal Science and Technology Project 2025A04J3631National Natural Science Foundation of China 82101825

6 · The paper itself

Abstract

Bacillus Calmette-Guérin (BCG) vaccination has well-documented off-target effects in early life, but the underlying molecular mechanisms remain incompletely understood. This study investigated whether BCG reprograms neonatal myeloid-derived suppressor cells (MDSCs) through oxidative phosphorylation (OXPHOS). After neonatal mice received a subcutaneous injection of BCG or PBS, the effects of BCG exposure on splenic monocytic (M-) and polymorphonuclear (PMN-) MDSCs were assessed. BCG vaccination significantly increased the expression of OXPHOS-related genes (Ndufab1, Sdhd, Uqcrfs1, Cox4i) and mitochondrial oxidative activity in both MDSC subsets. Seahorse analysis revealed a higher oxygen consumption rate in BCG-exposed PMN-MDSCs. Functional assays showed that BCG impaired MDSC-mediated T-cell suppression, with oligomycin treatment partially able to restore this suppressive capacity. Together, these findings indicate that BCG-induced OXPHOS potentiation contributes to the loss of MDSC immunosuppressive function in neonatal mice, providing a molecular mechanism for the non-specific immunomodulatory effects of BCG vaccination early in life.

Indexed as

Bacillus Calmette‐Guérinimmunometabolismimmunosuppressive functionmyeloid‐derived suppressor cellsoxidative phosphorylation

Identifiers

PMID42634385

DOI10.1002/2211-5463.70333

PMCPMC13501087

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.