ArticleYonsei medical journal2026
Prescription Patterns of Benzodiazepines and Opioid Analgesics in Adults with and without Major Psychiatric Disorders: A Nationwide Cohort Study.
Article in Yonsei medical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeUsing a time-lagged cohort design with temporal separation, we aimed to compare the prescribing patterns of benzodiazepine receptor agonists (BZRAs) and opioid analgesics between adults with and without major psychiatric disorders (PYs). MATERIALS AND
methodsThis retrospective nationwide longitudinal cohort study used South Korea's National Health Insurance Service database. Major PYs and covariates were identified during 2021 (exposure period). A time-lagged design was employed in which prescribing outcomes were tracked throughout 2022 to ensure temporal separation and precedence. After 1:1 propensity score matching, 570088 individuals (285044 per group) were included. Regular and continuous prescription was defined as ≥90 days of cumulative supply. Concurrent prescription was defined as ≥7 days of overlapping prescriptions.
resultsAfter matching, opioid analgesic prescription occurred in 21.9% of psychiatric patients versus 21.5% of controls [odds ratio (OR) 1.02, 95% confidence interval (CI) 1.01 to 1.03;
conclusionAdults with major PYs were more likely to receive long-term and overlapping prescriptions for BZRAs and opioid analgesics. Despite modest opioid increases, high concurrent prescribing-largely driven by baseline BZRA use-remains a significant safety concern requiring integrated monitoring.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.