ArticleMicrobiologyOpen2026
Genomic Epidemiology of Multidrug-Resistant Clinical Klebsiella pneumoniae From Pakistan.
Article in MicrobiologyOpen, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
backgroundAntimicrobial-resistant Klebsiella pneumoniae is a major clinical threat in Pakistan and the wider South Asian region, where genomic surveillance remains limited. We analyzed 122 publicly available human clinical K. pneumoniae whole-genome sequencing datasets from Pakistan to define lineage structure, antimicrobial-resistance determinants, virulence-associated loci, surface-antigen profiles, plasmid replicons, and genomic relatedness.
methodsReads were extracted, quality-filtered and assembled de novo, and assembly quality was assessed. Assemblies were characterized using Kleborate and ABRicate with the PlasmidFinder database. Trimmed reads were mapped to the K. pneumoniae MGH 78578 reference genome, and high-confidence biallelic SNPs (QUAL ≥ 30; per-isolate depth ≥ 10) were used to calculate pairwise genomic distances.
resultsThe cohort contained 23 sequence types and was dominated by ST15 (41/122, 33.61%), followed by ST48 (17/122, 13.93%), ST336 (11/122, 9.02%), ST711 (7/122, 5.74%), and ST3805 (7/122, 5.74%). Acquired resistance profiling detected 48 distinct antimicrobial-resistance genes. bla
conclusionThe cohort showed broad genomic diversity, near-universal bla
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