ArticleThe European journal of neuroscience2026
Long-Term Audiogenic Kindling Induces Pronounced Downregulation of the GABAergic System in the Hippocampus of Krushinsky-Molodkina Rats.
Article in The European journal of neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Long-Term Audiogenic Kindling Induces Pronounced Downregulation of the GABAergic System in the Hippocampus of Krushinsky-Molodkina Rats.The European journal of neuroscience · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Downregulation of inhibitory GABAergic transmission is closely connected with the development and progression of epilepsy; however, further studies are still needed to provide the complex and detailed picture of corresponding pathological alterations and their contribution to epileptogenesis. In the present study, we performed the comprehensive analysis of GABAergic system in the hippocampus of Krushinsky-Molodkina (KM) audiogenic rats, exposed to prolonged audiogenic kindling to reproduce the condition of temporal lobe epilepsy (TLE). According to the kindling protocol, KM rats were exposed to 21 daily seizure stimulations, whereas unstimulated (naive) KM rats were used as a control. Obtained results showed that 21-day kindling was associated with a pronounced decrease in the expression of glutamate decarboxylase 67 (GAD67) and co-localization of GAD67 with active cAMP-response element-binding protein (CREB), indicating reduced activity of GABAergic interneurons and GABA production. In addition, we observed decreased expression of synaptic vesicle glycoprotein 2A (SV2A) and lower co-localization of vesicular GABA transporter (VGAT) with active phosphorylated synapsin I, suggesting an impaired presynaptic GABAergic vesicle function. Moreover, dysregulation of GABA-A receptor and cation-chloride transporter expression was detected, which could also exacerbate the dysfunction of GABAergic system in the hippocampus. Thus, the results suggest that prolonged audiogenic kindling in KM rats, resulting in the stabilization of severe limbic seizures and increased mortality, is associated with a pronounced and multifaceted dysregulation of GABAergic transmission in the hippocampus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.