Evidence map›Paper›PMID 42634158›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Multi-omics identification of haptoglobin as a novel target for increased Alzheimer's disease risk associated with obesity through inhibiting the phagocytosis of Aβ by disease-associated microglia.

Xiaohang Qian, Zhongxuan Wang, Peijing Cui, Siyue Chen, Yang Xue, Yawen Yang, Jianhua Xu, Xiaoli Liu, Gangyu Ding, Huidong Tang

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In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Xiaohang Qian *Department of Geriatrics, Medical Center on Aging, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhongxuan Wang *Department of Geriatrics, Medical Center on Aging, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Peijing Cui *Department of Geriatrics, Medical Center on Aging, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Siyue ChenDepartment of Geriatrics, Medical Center on Aging, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yang XueDepartment of Geriatrics, Medical Center on Aging, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yawen YangDepartment of Rehabilitation Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jianhua XuDepartment of Neurology, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai, China.
Xiaoli LiuDepartment of Neurology, Shanghai Fengxian District Central Hospital, Shanghai, China.
Gangyu DingDepartment of Neurology, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai, China.
Huidong TangDepartment of Geriatrics, Medical Center on Aging, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

China Postdoctoral Science Foundation 2025M772189Shanghai Fengxian District Central Hospital Research Project YJKT-25-02-003Shanghai Fengxian District Science and Technology Commission Social Science and Technology Development Fund Project 20231207Shanghai Sailing Program 24YF2725800The Sixth People's Hospital of Shanghai medical group projects
6 · The paper itself

Abstract

introductionObesity may increase Alzheimer's disease (AD) risk, yet the underlying mechanisms remain unclear.

methodsWe investigated this link through global epidemiology, Mendelian randomization (MR), transcriptomics, clinical cohort validation, and mechanistic exploration.

resultsHigh body mass index (BMI)-attributable AD disability-adjusted life years and deaths increased 4-fold from 1990-2021, with projections indicating a tripling by 2050. MR analyses found that elevated BMI was genetically related to increased AD risk. Haptoglobin (HP) was identified as a core mediator between them. HP expression was correlated with plasma AD biomarkers and cognitive scores. Mechanistically, HP localized to plaque-associated microglia and suppressed microglial amyloid beta (Aβ) phagocytosis and DNAX activating protein of 12 kDa (Dap12)/Spleen tyrosine kinase (Syk) pathway with modulating disease-associated microglial transcriptional programs.

conclusionThis study identified HP as a strong candidate mediator linking obesity to AD pathogenesis through inhibiting the phagocytosis of Aβ by microglia.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesHaptoglobinsMicrogliaObesityPhagocytosisAnimalsBody Mass IndexFemaleHumansMaleMultiomicsAmyloid beta-PeptidesHaptoglobinsAlzheimer's diseaseAβ pathologyhaptoglobinmicrogliaobesity

Identifiers

PMID42634158
PMCPMC13500896

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.