ReviewImmunological reviews2026
B1 Cells for Life.
Review in Immunological reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
B cells are recognized and appreciated as (the only) immune system elements that produce antibodies. However, B cells are not all the same, and subpopulations differ in many respects. A particularly intriguing and consequential B cell subpopulation is designated B1 cells. B1 cells arise early in development, persist in life via self-renewal, and generate so-called "natural" antibodies spontaneously and continuously with unique characteristics and targets. The journey of B1 cell discovery began almost half a century ago in mice. Within just the last 15 years, the characteristics of mouse B1 cells were used to identify B1 cells in people. Human B1 cell antibodies provide defense against microbial pathogens and homeostatic control of toxic byproducts and cellular debris. However, B1 cells decline in number and function with advancing age, suggesting this loss may underlie the increased risk of older individuals to infectious disease, as well as several chronic diseases of aging (the Rheostat Hypothesis).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.