Evidence map›Paper›PMID 42633875›Full record

ArticlePharmacological research2026

Site and mechanism of BK channel inhibition and cerebral artery constriction by pregnenolone.

Kelsey C North, Shiwani Thapa, Steven C Mysiewicz, Andrew A Shaw, Gregg E Homanics, Anna N Bukiya, Alex M Dopico

Abstract read
In one paragraph

Article in Pharmacological research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kelsey C NorthDepartment of Pharmacology, Addiction Science, and Toxicology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38103, USA.
Shiwani ThapaDepartment of Pharmacology, Addiction Science, and Toxicology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38103, USA.
Steven C Mysiewicz
Andrew A ShawDepartment of Pharmacology, Addiction Science, and Toxicology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38103, USA.
Gregg E HomanicsDepartment of Anesthesiology and Perioperative Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Anna N BukiyaDepartment of Pharmacology, Addiction Science, and Toxicology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38103, USA.
Alex M DopicoDepartment of Pharmacology, Addiction Science, and Toxicology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38103, USA. Electronic address: adopico@uthsc.edu.

Funding

Role of noncoding RNA in alcohol actionU01AA020889 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sean P Farris, Gregg E. Homanics · 2011 to 2026
$7.1M
Regulation of arterial diameter through specific sensing of endogenous steroids and novel nonsteroidal analogs by BK channel subunitsR01HL147315 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI DOPICO, ALEX M. · 2019 to 2022
$2.4M
Pregnenolone constricts cerebral vascular arteries through the direct modulation of BK ion channelsF31HL156290 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI NORTH, KELSEY CLELAND · 2021 to 2022
$67k
NHLBI NIH HHS F31 HL156290NHLBI NIH HHS R01 HL147315NIAAA NIH HHS U01 AA020889
6 · The paper itself

Abstract

Circulating vasoactive steroids including estrogens, androgens, progesterone, and bile acids modulate the activity of voltage/Ca

Indexed as

Cerebral ArteriesLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsPotassium Channel BlockersPregnenoloneVasoconstrictionAnimalsHumansMaleMiceMice, Inbred C57BLKcnma1 protein, mouseLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsPotassium Channel BlockersPregnenoloneCerebral artery constrictionCRAC motifKcnma1MaxiK channelsPregnenoloneSteroidsVascular smooth muscle

Identifiers

PMID42633875
PMCPMC13662901

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.