Evidence map›Paper›PMID 42633819›Full record

ArticleBrain, behavior, and immunity2026

Higher polygenic scores for C-reactive protein is associated with lower striatal reward magnitude coding in early adolescents.

Lily A Heritage, Iris Ka-Yi Chat, Jonathan Ahern, Robert J Loughnan, Robin L Aupperle, Chun Chieh Fan, Martin P Paulus, Wesley K Thompson, Haixia Zheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lily A HeritageLaureate Institute for Brain Research, Tulsa, OK, USA.
Iris Ka-Yi ChatDepartment of Psychology, University of California, Los Angeles, USA.
Jonathan AhernCenter for Population Neuroscience and Genetics, Tulsa, OK, USA; Department of Cognitive Science, University of California, San Diego, La Jolla, CA, USA.
Robert J LoughnanCenter for Population Neuroscience and Genetics, Tulsa, OK, USA; J. Craig Venter Institute, La Jolla, CA, USA.
Robin L AupperleLaureate Institute for Brain Research, Tulsa, OK, USA; Oxley College of Health and Natural Sciences, The University of Tulsa, Tulsa, OK, USA.
Chun Chieh FanLaureate Institute for Brain Research, Tulsa, OK, USA; Center for Population Neuroscience and Genetics, Tulsa, OK, USA; Department of Radiology, University of California School of Medicine, San Diego, CA, USA.
Martin P PaulusLaureate Institute for Brain Research, Tulsa, OK, USA; Oxley College of Health and Natural Sciences, The University of Tulsa, Tulsa, OK, USA.
Wesley K ThompsonLaureate Institute for Brain Research, Tulsa, OK, USA; Center for Population Neuroscience and Genetics, Tulsa, OK, USA.
Haixia ZhengLaureate Institute for Brain Research, Tulsa, OK, USA; Oxley College of Health and Natural Sciences, The University of Tulsa, Tulsa, OK, USA. Electronic address: hzheng@laureateinstitute.org.

Funding

PREVENTION RESEARCH TRAINING:URBAN CHILDREN'S MENT HLTHT32MH015750 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHRISTINE DUNKEL SCHETTER · 1985 to 2026
$6.2M
Effects of pandemic-related disruption to social connectedness on the brain and emotional wellbeing in adolescentsR01MH128959 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Fiona C Baker, Chun Chieh Fan · 2022 to 2026
$3.9M
Identifying and quantifying genetic effects on neurodevelopmental trajectories in adolescentsR01MH122688 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FAN, CHUN CHIEH · 2020 to 2024
$1.8M
Cytomegalovirus, Brain Alterations, and Depression: Decoding Neuroinflammatory Pathways for Effective InterventionK01MH136403 · NIMH · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI Haixia Zheng · 2024 to 2026
$626k
NIMH NIH HHS K01 MH136403NIMH NIH HHS R01 MH122688NIMH NIH HHS R01 MH128959NIMH NIH HHS T32 MH015750
6 · The paper itself

Abstract

Low-grade inflammation has been linked to altered reward processing and risk for mood disorders in adults, yet it remains unclear whether genetic liability for inflammation is associated with reward circuitry function before the typical age of onset for depression and anhedonia. Using data from the Adolescent Brain and Cognitive Development Study, we examined whether a polygenic score for C-reactive protein (PGS-CRP) was associated with striatal activation during reward processing in 4,830 children of European ancestry (ages 9-10). Participants com pleted the Monetary Incentive Delay task during functional MRI. Linear mixed-effects models tested associations between high versus low PGS-CRP and activation in the nucleus accumbens, caudate, and putamen during reward and loss anticipation and feedback, adjusting for sociodemographic, anthropometric, scanner, and genetic ancestry covariates. Higher PGS-CRP was associated with attenuated activation across all three striatal regions (i.e., the nucleus accumbens, caudate, and putamen) during anticipation of large relative to small rewards at baseline (all p

Indexed as

fMRI Monetary incentive delay taskInflammationPolygenic score for C-reactive proteinReward anticipationStriatum

Identifiers

PMID42633819
PMCPMC13690263

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.