Evidence map›Paper›PMID 42633604›Full record

ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2026

Urinary dysfunction in spinal meningiomas: a significant disease severity marker in a cohort of 165 patients.

Lorenzo Aureli, Mauro Palmieri, Alexandro Paccapelo, Federica Novegno, Antonio Santoro, Maurizio Salvati, Alessandro Frati, Alessandro Pesce

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Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Lorenzo AureliSystems Medicine Department - Department of Neurosurgery, University of Rome Tor Vergata, Rome, Italy. lorenzo.aureli@ptvonline.it.
Mauro PalmieriHuman Neurosciences Department - Neurosurgery Division, Sapienza University of Rome, Rome, Italy.
Alexandro PaccapeloEpidemiology and Statistics, IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola, Bologna, Italy.
Federica NovegnoSystems Medicine Department - Department of Neurosurgery, University of Rome Tor Vergata, Rome, Italy.
Antonio SantoroHuman Neurosciences Department - Neurosurgery Division, Sapienza University of Rome, Rome, Italy.
Maurizio SalvatiSystems Medicine Department - Department of Neurosurgery, University of Rome Tor Vergata, Rome, Italy.
Alessandro FratiHuman Neurosciences Department - Neurosurgery Division, Sapienza University of Rome, Rome, Italy.
Alessandro PesceSystems Medicine Department - Department of Neurosurgery, University of Rome Tor Vergata, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSpinal meningiomas (SM) are generally benign tumours with favourable surgical outcomes. However, their potential to impair sphincter function-particularly bladder control-remains insufficiently investigated. Bladder dysfunction, ranging from urge incontinence to complete urinary incontinence, may significantly impair quality of life and correlate with both neurological status and surgical outcomes.

objectiveThis study aimed to determine whether preoperative clinically reported urinary impairment is associated with disease severity in surgically treated spinal meningiomas. Secondary aims were to evaluate its relationship with symptom duration, neurological status, extent of resection, and follow-up functional outcome.

methodsFrom a multicentric cohort of 270 SM operated between 1976 and 2023, 165 cases were retrospectively analysed. Patients were stratified according to preoperative patient-reported urinary status. Neurological function was assessed using Frankel and McCormick scales, while extent of resection was classified according to Simpson grade. Associations were explored using group comparisons and Spearman correlation. Univariable and multivariable logistic regression analyses were performed to identify factors associated with urinary dysfunction. Model discrimination was assessed using ROC analysis, and an exploratory nomogram was generated from the final multivariable model.

resultsSymptom duration was longer in patients with sphincter impairment (p < 0.001). Extent of resection differed between groups (p = 0.007). Neurological status was worse both preoperatively and at follow-up, as reflected by Frankel (p = 0.009 preoperatively; p = 0.018 at follow-up) and McCormick grades (p = 0.010 both preoperatively and at follow-up).

conclusionPatient-reported urinary dysfunction was associated with longer symptom duration and worse neurological status in spinal meningiomas, underlining its role as a clinically relevant marker of disease severity. These findings should be interpreted as associative rather than causal, and prospective studies with standardized neuro-urological assessment are required.

Indexed as

Extent of resectionLower urinary tract dysfunctionNeurological outcomeSpinal cord compressionSpinal meningiomas

Identifiers

PMID42633604

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