Evidence map›Paper›PMID 42633493›Full record

ArticleADMET & DMPK2026

Mechanisms of action of the hexane extract of

Julia Chaves Scaffo, Sofia Trindade Mussi da Silva, Vitor Won-Held Rabelo, Leandro Stefano Sangenito, Lucas da Silva Abreu, Thaís P Mello, Leandro Rocha, André Luis Souza Dos Santos

Abstract read
In one paragraph

Article in ADMET & DMPK, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Julia Chaves ScaffoGraduate Program in Applied Sciences for Health Products, Faculty of Pharmacy, Fluminense Federal University (UFF), Niterói, Brazil.ORCID https://orcid.org/0000-0001-6214-7778
Sofia Trindade Mussi da SilvaLaboratory of Chemistry of Natural Products, Institute of Chemistry, Fluminense Federal University (UFF), Niterói, Brazil.ORCID https://orcid.org/0009-0003-5215-5864
Vitor Won-Held RabeloDepartment of Virology, Paulo de Góes Microbiology Institute, Center of Health Science, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0001-5303-6814
Leandro Stefano SangenitoLaboratory of Advanced Studies of Emerging and Resistant Microorganisms, Paulo de Góes Microbiology Institute, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0002-3715-1967
Lucas da Silva AbreuLaboratory of Chemistry of Natural Products, Institute of Chemistry, Fluminense Federal University (UFF), Niterói, Brazil.ORCID https://orcid.org/0000-0001-5620-8095
Thaís P MelloCollection of Environment and Health Fungi (CFAS), Fungal Section, Department of Microbiology, National Institute for Quality Control in Health (INCQS), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil.ORCID https://orcid.org/0000-0002-5820-2241
Leandro RochaGraduate Program in Applied Sciences for Health Products, Faculty of Pharmacy, Fluminense Federal University (UFF), Niterói, Brazil.ORCID https://orcid.org/0000-0003-0484-1918
André Luis Souza Dos SantosLaboratory of Advanced Studies of Emerging and Resistant Microorganisms, Paulo de Góes Microbiology Institute, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0003-0821-8592

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose: Microbial resistance is a major global health concern. Methicillin-resistant Staphylococcus aureus is particularly relevant due to its clinical significance, virulence and adaptability. In the search for novel antimicrobial agents, natural products emerged as important sources of bioactive molecules. Previous studies have identified Experimental approach: We evaluated the susceptibility, mechanisms of action and toxicity of Key results: The heHb and uliB demonstrated strong antibacterial activity, exhibiting MICs of 3.125 to 6.25 μg mL Conclusion: UliB is likely a key bioactive compound of

Indexed as

antimicrobial activitybacterial infectionsbiofilmGalleria mellonellaNatural productstoxicity

Identifiers

PMID42633493
PMCPMC13499665

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.