ArticleInternational journal of general medicine2026
The Diagnostic Value of Heparin-Binding Protein for Sepsis-Associated Acute Kidney Injury: A Retrospective Single-Center Study.
Article in International journal of general medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To explore the value of heparin-binding protein (HBP) in the diagnosis of sepsis-associated acute kidney injury (SA-AKI) in patients with sepsis. Methods: This retrospective single-center study enrolled 114 patients with sepsis admitted between January 2023 and January 2025. Patients were divided into SA-AKI group (n=76) and non-SA-AKI group (n=38) based on the presence of AKI. Baseline clinical data were collected for both groups. Venous blood samples were obtained at ICU admission (within 30 minutes of arrival, T0) and at 24 h (T24), 48 h (T48), and 72 h (T72) thereafter for measurement of HBP and other infection-related biomarkers. General characteristics and dynamic changes in HBP levels were compared between the two groups. ROC curve analysis was performed to evaluate the diagnosticvalue of each biomarker for SA-AKI. Results: SOFA score, length of mechanical ventilation, and 28-day mortality were significantly higher in the SA-AKI group than in the non-SA-AKI group (all Conclusion: HBP demonstrates high early predictive value for SA-AKI in ICU patients with sepsis, with diagnostic performance superior to that of PCTand IL-6. HBP may serve as a promising early biomarker for the diagnosis of SA-AKI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.