ArticleJournal of Taibah University Medical Sciences2026
Evolutionary study of oncogenes and tumor suppressor genes in breast carcinoma.
Article in Journal of Taibah University Medical Sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
Objectives: Cancer involves abnormal cell proliferation and migration throughout the body. Genetic changes occurring in hereditary breast cancer led to the activation of oncogenes, resulting in gain-of-function effects. This study was designed to conduct a phylogenetic analysis of breast cancer-related oncogenes and tumor suppressor genes families in humans relevant to different species and their potential against breast cancer. Methods: The protein sequence data were retrieved from Ensembl Genome Browser and NCBI databases. BLAST searches were performed to obtain FASTA sequences of selected vertebrates. Multiple sequence alignment was conducted using ClustalW in MEGA X, followed by the construction of neighbor-joining phylogenetic trees in circular format. Tree robustness was assessed through bootstrap analysis with 500 pseudoreplicates. Results: Among the eleven oncogenes, the Conclusions: In conclusion, variability in paralogue numbers among oncogenes and tumor suppressor genes, with some genes having multiple paralogues and others, like
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