ArticleCureus2026
From Dieulafoy's Lesion to Gastrointestinal Stromal Tumor: A Case of Recurrent Upper Gastrointestinal Bleeding.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Dieulafoy's lesion and gastrointestinal stromal tumors (GISTs) are uncommon causes of upper gastrointestinal (GI) bleeding. We report a rare case of recurrent upper GI bleeding in a 71-year-old male who initially presented in 2017 with hematemesis, melena, and hemodynamic instability. Upper GI endoscopy identified a fundal Dieulafoy's lesion, which was successfully treated with endoscopic clipping. Seven years later, the patient re-presented with melena, fatigue, dizziness, and symptomatic anemia requiring blood transfusion. Repeat endoscopy demonstrated a 6-cm ulcerated submucosal mass in the gastric fundus. Endoscopic ultrasound showed a lesion arising from the fourth layer of the gastric wall, and fine-needle aspiration confirmed a low-grade mixed-type GIST. Computed tomography demonstrated a localized enhancing gastric mass without evidence of metastatic disease. Following multidisciplinary review, the patient underwent successful laparoscopic wedge resection. Histopathological examination confirmed a completely excised low-risk gastric GIST measuring 6.5 × 5.5 × 4.5 cm with a mitotic rate of 3 mitoses per 5 mm² and negative surgical margins. The postoperative course was uneventful. This case highlights the importance of reassessing patients with recurrent GI bleeding despite a previously identified bleeding source. The unusual temporal association between a Dieulafoy's lesion and a subsequently diagnosed gastric GIST in the same anatomical region underscores the need for continued diagnostic vigilance and multidisciplinary management in atypical presentations of upper GI bleeding.
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