ReviewMaterials today. Bio2026
Metal coordination at biological interfaces: Mechanisms, therapeutics, and translation.
Review in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metal ions are integral to biological systems, serving as catalytic cofactors, structural components, and mediators of key cellular signaling pathways. Understanding their interactions with bioactive molecules at biointerfaces provides valuable insights into the development of metal-based drugs, therapeutic biomaterials, and innovative nanomedicines. This review adopts a bio-interface-centered framework that integrates coordination chemistry, surface chemistry, and biomolecular recognition, underscoring how coordination geometry, ligand kinetics, redox behavior, and hard/soft acid/base preferences affect the interactions of metal complexes with DNA, proteins, lipids, and glycoconjugates. These interactions regulate diverse cellular processes, such as mitochondrial function, signal transduction cascades, and programmed cell death mechanisms, including apoptosis and ferroptosis. This manuscript outlines the major classes of clinically significant metal complexes, along with emerging systems, including metal-organic frameworks, polymeric carriers, and artificial metalloenzymes, designed to provide targeted delivery and catalytic activity at biological interfaces. In particular, this review focuses on the combination of coordination chemistry, nanotechnology, and chemical biology to develop stimuli-responsive frameworks capable of targeted delivery and multifunctional therapeutic effects. This review further examines the role of metal coordination in biomolecular recognition, biointerface regulation, pharmacokinetic behavior, toxicity, and therapeutic performance, thereby linking atomic-level coordination chemistry with cellular and translational outcomes. This bio-interface-centered perspective distinguishes the present review from prior work focused separately on metallodrugs, bioinorganic mechanisms, or coordination chemistry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.