ArticleBrain, behavior, & immunity - health2026
Preventive effect of ulinastatin on postoperative cognitive dysfunction through modulation of the gut microbiome: evidence from short-chain fatty acids.
Article in Brain, behavior, & immunity - health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: Increasing evidence indicates that gut dysbiosis and gut-brain axis dysfunction contribute to postoperative cognitive dysfunction (POCD) following general anaesthesia. Although ulinastatin, a urinary trypsin inhibitor, has been reported to exert anti-inflammatory and neuroprotective effects, its role in the gut microbiome and microbiome-related metabolites in POCD remains unclear. Methods: A total of 30 18-month-old male Sprague-Dawley rats were randomly allocated to the Ulinastatin group or the Control group. Ulinastatin (50,000 U/mL) or normal saline (1 mL) was intraperitoneally administered before general anaesthesia, which was maintained with isoflurane 1.5 vol% for 2 h. Cognitive function was assessed using the Y-maze test. Results: Y-maze performance did not differ between groups before general anaesthesia. However, a significant decline after anaesthesia was observed only in the Control group ( Conclusion: Preoperative administration of ulinastatin prevented cognitive decline after general anaesthesia. The protective effect of ulinastatin was associated with control of gut dysbiosis.
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