ArticleBrain & spine2026
Brain tumor surgery affecting the left frontal aslant tract and clinical outcome: a study of 23 glioma patients.
Article in Brain & spine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The frontal aslant tract (FAT) is associated with speech initiation, though its surgical relevance remains debated. The arcuate fasciculus (AF) is linked to phonological and semantic processing, with a well-established role for lasting outcomes. Research question: To investigate the impact of isolated and combined FAT and AF disruption on transient and lasting language deficits in glioma patients. Material and methods: We retrospectively analyzed 23 patients with non-contrast-enhancing IDH-mutant gliomas affecting the left FAT. Language was assessed pre-, intra-, and postoperatively. Awake speech mapping using Penfield stimulation was performed in 15 (65.2%) and neurophysiological monitoring under general anaesthesia in 8 patients. The FAT and AF were reconstructed by diffusion tensor imaging tractography, and tract integrity was classified as intact, partially disrupted, or fully disrupted. Postoperative and follow-up language deficits were correlated with the degree of tract disruption. Results: FAT disruption correlated with transient deficits (τ = 0.36, p = 0.059). AF involvement was associated with transient (τ= 0.30, p = 0.088) and persistent aphasia (τ = 0.53, p = 0.033). Combined FAT and AF damage was linked to an increased deficit of both immediate (τ = 0.44, p = 0.022) and lasting (τ = 0.49, p = 0.046) language outcomes. Discussion and conclusion: FAT injury contributes to transient aphasic symptoms, whereas AF disruption reflects persistent impairment. Concurrent FAT and AF involvement amplifies both short-term and lasting deficits, supporting a network-based approach to tract preservation in glioma surgery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.