Evidence map›Paper›PMID 42633234›Full record

ArticleJournal of oral biology and craniofacial research

Salivary telomere length in oral leukoplakia and oral squamous cell carcinoma: A preliminary case- control study.

Anoushka Chauhan, Punnya V Angadi, Bhushan B Kulkarni, Mehreen S Belawadi, Rashmi Patil, Karthiga Sakthi

Abstract read
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In one paragraph

Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Anoushka ChauhanDepartment of Oral Pathology and Microbiology, KLE VK Institute of Dental Sciences and Hospital, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India.
Punnya V AngadiDepartment of Oral Pathology and Microbiology, KLE VK Institute of Dental Sciences and Hospital, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India.
Bhushan B KulkarniDr. Prabhakar Kore Basic Science Research Centre (BSRC) and Jawaharlal Nehru Medical College, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India.
Mehreen S BelawadiDr. Prabhakar Kore Basic Science Research Centre (BSRC) and Jawaharlal Nehru Medical College, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India.
Rashmi PatilDepartment of Oral and Maxillofacial Surgery, KLE VK Institute of Dental Sciences and Hospital, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India.
Karthiga SakthiDepartment of Public Health Dentistry, KLE VK Institute of Dental Sciences and Hospital, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To evaluate salivary telomere length as a potential non-invasive exploratory biomarker for early molecular alterations associated with oral leukoplakia and oral squamous cell carcinoma. Methods: Forty-five participants were initially recruited: 15 healthy controls, 15 leukoplakia cases, and 15 oral squamous cell carcinoma (OSCC) cases. Two milliliters of unstimulated saliva was collected, and genomic DNA was isolated using the QIAamp DNA Mini Kit (Qiagen, Hilden, Germany). Relative telomere length (RTL) was assessed using quantitative real-time PCR via the comparative Results: The mean relative telomere length (RTL) ratios Conclusion: Salivary telomere length exhibits substantial inter-individual variability and a non-significant increasing trend from healthy controls to oral leukoplakia and OSCC. These preliminary findings suggest that relative telomere length may not be a reliable standalone biomarker in its current form and warrants further validation in larger, longitudinal studies.

Indexed as

Oral leukoplakiaOral potentially malignant disorderOral squamous cell carcinomaRelative Telomere lengthSalivaSalivary biomarker

Identifiers

PMID42633234
PMCPMC13499174

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