Evidence map›Paper›PMID 42633203›Full record

ArticleNon-coding RNA research2026

LncRNA-driven alternative splicing landscapes associate with survival outcomes in ovarian cancer.

Yan Cao, Jian Zhao, Shan He, Qiong Wu, Yixuan Wang, Jing Wu, Jingjing Liu, Yuan Xie, Xiaofeng Song

Abstract read
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In one paragraph

Article in Non-coding RNA research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yan CaoDepartment of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, 211106, China.
Jian ZhaoDepartment of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, 211106, China.
Shan HeDepartment of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, 211106, China.
Qiong WuDepartment of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, 211106, China.
Yixuan WangDepartment of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, 211106, China.
Jing WuSchool of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, 211166, China.
Jingjing LiuDepartment of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, 211106, China.
Yuan XieDepartment of Radiology, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, 210018, China.
Xiaofeng SongDepartment of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, 211106, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian cancer (OV) has the highest mortality rate among gynecological malignancies, with limited improvement in survival despite emerging treatments, underscoring an urgent need for novel diagnostic and therapeutic targets. Alternative splicing (AS) plays critical roles in OV progression, and long non-coding RNAs (lncRNAs) have recently been implicated as splicing regulators in tumor development. However, the landscape of lncRNA-mediated splicing dysregulation in OV remains unexplored. Here, we performed a genome-wide analysis integrating 207 differentially expressed lncRNAs and 1201 abnormal AS events from OV transcriptomes, identifying 2545 co-expression pairs. By constructing multi-layer regulatory networks incorporating splicing factors, transcription factors, and microRNAs, and applying a restart random walk algorithm seeded with oncogenes, we prioritized 29 hub splicing-regulatory lncRNAs, of which 15 are significantly associated with OV survival. This study provides novel lncRNA biomarkers and mechanistic insights into splicing dysregulation in OV.

Indexed as

Alternative splicinglncRNAOvarian cancerSplicing-regulatory network

Identifiers

PMID42633203
PMCPMC13499208

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.