Evidence map›Paper›PMID 42633200›Full record

ArticleBrain & spine2026

Degenerative spinal stenosis may influence Normal Pressure Hydrocephalus (NPH)-related imaging characteristics.

Hanna Böttner, Kerstin Jütten, Frederic DeBeukelaer, Klaus Radermacher, Anne Benninghaus, Christian Andreas Mueller, Hans Clusmann, Chuh-Hyoun Na

Abstract read
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In one paragraph

Article in Brain & spine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hanna BöttnerDepartment of Neurosurgery, RWTH Aachen University, Pauwelsstraße 30, Aachen, 52074, Germany.
Kerstin JüttenDepartment of Neurosurgery, RWTH Aachen University, Pauwelsstraße 30, Aachen, 52074, Germany.
Frederic DeBeukelaerDepartment of Diagnostic and Interventional Neuroradiology, RWTH Aachen University, Pauwelsstraße 30, Aachen, 52074, Germany.
Klaus RadermacherChair of Medical Engineering, RWTH Aachen University, Pauwelsstraße 20, Aachen, 52074, Germany.
Anne BenninghausChair of Medical Engineering, RWTH Aachen University, Pauwelsstraße 20, Aachen, 52074, Germany.
Christian Andreas MuellerDepartment of Neurosurgery, RWTH Aachen University, Pauwelsstraße 30, Aachen, 52074, Germany.
Hans ClusmannDepartment of Neurosurgery, RWTH Aachen University, Pauwelsstraße 30, Aachen, 52074, Germany.
Chuh-Hyoun NaDepartment of Neurosurgery, RWTH Aachen University, Pauwelsstraße 30, Aachen, 52074, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The etiology of NPH is unknown, but might be related to altered craniospinal compliance caused by spinal canal narrowing, as has been suggested by in-vitro simulation studies. However, clinical evidence is lacking. We explored associations between cervical (CS) and lumbar (LS) spinal stenoses, and NPH-imaging characteristics. Methods: Spinal MRI of NPH-patients scheduled for shunt-surgery was retrospectively evaluated by measuring the minimal dural sac cross-sectional area (DSCSA), and anterior-posterior diameter (AP) in CS and LS. Cranial-CT was evaluated regarding Evans-Index, callosal angle (CA), and Radscale-Score. CS and LS were each sub-grouped by median split into small/large DSCSA and small/large AP, and CT-parameters compared using Mann-Whitney-U-Tests, tested one-sided ( Results: Out of 426 NPH-patients screened, 114 patients had spinal-MRI. Of those with cervical-MRI (n = 100), 90% had CS, of those with lumbar-MRI (n = 86), 71% had LS. Among these, 60 patients had cervical and lumbar MRI, of which 63% showed combined CS and LS. CA was larger in CS patients with small as compared to large AP ( Conclusions: Spinal stenosis might be associated with NPH-related imaging characteristics. Prospective studies should investigate the potential pathophysiological impact of degenerative spine-disease on NPH.

Indexed as

Callosal angleCraniospinal complianceCSF flow-dynamicsNormal pressure hydrocephalusSpinal stenosis

Identifiers

PMID42633200
PMCPMC13499192

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.