ArticleThe journal of allergy and clinical immunology. Global2026
Prevalence and features of eosinophilic gastrointestinal disorders using the large real-world TriNetX database.
Article in The journal of allergy and clinical immunology. Global, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: There are substantial questions concerning the epidemiology and demographics of eosinophilic gastrointestinal disorders (EGID). We queried TriNetX, a large electronic medical record database, to assess EGID demographics. Objectives: Our objective for this study was to characterize the prevalence, demographic features, disease overlap, and treatment patterns of patients with EGID using a large multicenter electronic health record database. Methods: TriNetX, a deidentified patient database derived from 92 health care organizations and a total population of 129,260,452 patients, was queried for EGID. Cases were identified by ICD codes (eosinophilic esophagitis [EoE] K20, eosinophilic gastritis/enteritis [EoG/EoN] K52.81, eosinophilic colitis [EoC] K52.82) and endoscopy occurrence. Demographic and clinical characteristics were analyzed. Results: We identified 77,726 EoE, 6,554 EoG/EoN, and 2,898 EoC cases. Prevalence was approximately 1:1,673, 1:19,842, and 1:44,873, respectively. Multiple EGID occurred in 5% of all patients but in 47% of those with EoG/EoN. EGID was most common in non-Hispanic White individuals (79%). Male predominance was observed in EoE (59%) but not EoG/EoN (46%) or EoC (45%). Mean patient ages at query were 39, 31, and 40 years for EoE, EoG/EoN, and EoC, respectively ( Conclusions: We identified the largest reported population of patients with EGID (77,726 cases); our findings substantiate their rarity (0.002-0.5% prevalence), male predominance limited to EoE, substantial co-occurrence of multiple EGID, and distinct age distribution of EoG/EoN. The identified cohort and approaches provide opportunities for further research.
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