ArticleCureus2026
Postoperative Anaemia Severity as a Superior Predictor of Short-Term Adverse Outcomes Following Vascular Surgery: A Retrospective Cohort Study at a UK Teaching Hospital Trust.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
Background Perioperative anaemia is highly prevalent in vascular surgery, yet the independent prognostic significance of postoperative anaemia severity remains poorly characterised compared with preoperative anaemia. This study evaluated the association between postoperative anaemia severity and short-term adverse outcomes and compared its predictive utility with preoperative and persistent perioperative anaemia models. Methods A retrospective single-centre cohort study was conducted at Nottingham University Hospitals NHS Trust. All patients undergoing inpatient vascular surgical procedures between July and October 2024 were identified. After excluding day-case procedures and patients with incomplete perioperative haemoglobin (Hb) data, 196 patients were included. Anaemia severity was categorised using World Health Organisation (WHO) sex-specific thresholds into four levels: no anaemia, mild (Hb 110-129 g/L), moderate (Hb 80-109 g/L), and severe (<80 g/L). The primary outcome was a 30-day composite of prolonged hospitalisation (seven days or more), unplanned readmission, and all-cause mortality. Three binomial logistic regression models were compared using Akaike Information Criterion (AIC), Nagelkerke R², and area under the receiver operating characteristic curve (AUC). Results Among 196 patients (mean age 69±15.4 years), the 30-day composite adverse outcome occurred in 158 (80.6%), including prolonged hospitalisation in 140 (71.4%), unplanned readmission in 50 (25.5%) and mortality in 16 (8.2%). A clinically significant perioperative haematological shift was observed: mean Hb declined from 115±18.9 g/L preoperatively to 105±17.9 g/L postoperatively, while moderate anaemia increased from 60 (30.6%) to 99 (50.5%) and severe anaemia doubled from 9 (4.6%) to 19 (9.7%). Subgroup comparisons revealed that baseline demographics and comorbidities had no significant association with the 30-day composite adverse outcome, including gender X
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