Evidence map›Paper›PMID 42633185›Full record

ReviewBiochemistry and biophysics reports2026

Baicalin and CNS-related diseases: new insights into neuroprotective potentials based on underlying mechanisms.

Yasin Rashidi, Amir Hossein Barjasteh, Mehran Ilaghi, Ali Pozvei, Mohamadreza Soltanpour, Sharareh Jahangiri, Mehrsa Radmanesh, Alireza Pourbafrani, Seyed Hasan Hosseini Faegh, Fatemeh Bagheri and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Review in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yasin RashidiStudent Research Committee, Kashan University of Medical Sciences, Kashan, Iran.
Amir Hossein BarjastehFaculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mehran IlaghiInstitute of Neuropharmacology, Kerman Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Ali PozveiStudent Research Committee, Kashan University of Medical Sciences, Kashan, Iran.
Mohamadreza SoltanpourStudent Research Committee, Kashan University of Medical Sciences, Kashan, Iran.
Sharareh JahangiriAnesthesiologist, Tehran University of Medical Sciences, Tehran, Iran.
Mehrsa RadmaneshIsfahan University of Medical Sciences, Isfahan, Iran.
Alireza PourbafraniDepartment of Motor Behavior, Faculty of Physical Education and Sport Sciences, Allameh Tabataba'i University, Tehran, Iran.
Seyed Hasan Hosseini FaeghFaculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Fatemeh BagheriResearch Hub Institute, Tehran, Iran.
Shahrzad ZarifbargiGolestan University of Medical Sciences, Gorgan, Iran.
Mohammad Hossein PourhanifehResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Central nervous system (CNS)-associated diseases such as neurological (including cerebral ischemia-reperfusion injury and stroke, Parkinson's disease, Alzheimer's disease, traumatic brain injury, and spinal cord injury) and psychological (including depression, anxiety, attention deficit hyperactivity disorder, and dementia) diseases are known as serious problems for public health worldwide. These diseases contribute to the occurrence of several disabilities and even death in affected individuals, and also decrease their quality of life. Therefore, discovering effective complementary treatments is essential. Recently, baicalin, a multifunctional natural product, has attracted much attention because of its therapeutic potentials in various diseases. Moreover, it has been shown that this agent can regulate key cellular and molecular processes in human diseases. In the case of CNS-related diseases, this review article aimed to summarize and discuss the available data from in vivo and in vitro investigations on the therapeutic application of baicalin, based on underlying mechanisms.

Indexed as

ApoptosisBaicalinCerebral infarctionMicroglial activationNeurodegenerationOxidative stress

Identifiers

PMID42633185
PMCPMC13499145

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.