ArticleRadiology case reports2026
The solitary skull mass: An atypical presentation of anaplastic large cell lymphoma.
Article in Radiology case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Anaplastic large cell lymphoma (ALCL) is a rare type of non-Hodgkin lymphoma characterized by neoplastic proliferation of CD30-positive T lymphocytes. Three distinct genotypic subtypes have been described, each of which demonstrates distinct biomolecular features and phenotypic manifestations. Anaplastic lymphoma kinase (ALK)-positive ALCL typically affects adolescents and young adults and has a favorable prognosis. ALK-negative ALCL is more common in middle-aged adults and has a relatively poor prognosis with higher rates of treatment resistance and relapse. Breast implant-associated ALCL (BIA-ALCL) is an uncommon subtype that arises within the fibrous capsule or pericapsular fluid surrounding breast implants. Individuals with ALK-positive ALCL usually present with lymphadenopathy, fever, night sweats, and fatigue. Osseous involvement is rare. We present the case of a 21-year-old male who presented with a single tender, palpable skull mass and was subsequently found to have ALK-positive ALCL. In addition, we review the differential diagnosis for calvarial lesions as well as imaging features and management of ALK-positive ALCL. This case emphasizes that lymphoma should remain an important diagnostic consideration when evaluating an aggressive transcalvarial mass.
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