Evidence map›Paper›PMID 42633131›Full record

ArticleiScience2026

The shifting global thalassemia burden and lessons from Chineseintegrated control strategy.

Cheng Jin, Zhilin Hu, Yue Li, Qihong Lin, Jiaming Yu, Qian Zhang, Mingjing Luo, Chunlan Yang, Xiaohui Zhou, Feiqiu Wen and 2 more

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Cheng JinDepartment of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, China.
Zhilin HuDepartment of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, China.
Yue LiDepartment of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, China.
Qihong LinDepartment of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, China.
Jiaming YuDepartment of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, China.
Qian ZhangDepartment of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, China.
Mingjing LuoDepartment of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, China.
Chunlan YangDepartment of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, China.
Xiaohui ZhouDepartment of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, China.
Feiqiu WenDepartment of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, China.
Wenyi JinDepartment of Orthopaedics, Renmin Hospital of Wuhan University, Wuhan, China.
Sixi LiuDepartment of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thalassemias impose a substantial but highly uneven global health burden. Using Global Burden of Disease 2023 estimates, we quantified the prevalence, mortality, and disability-adjusted life years (DALYs) of thalassemias across 204 countries and territories from 1980 to 2023 and evaluated health system performance with frontier analysis. Although the global age-standardized DALY rate declined by 44.8% from 1990 to 2023, this overall reduction masks stark regional and demographic divergences. Specifically, the burden surged among women aged 20-54 years in the Caribbean and those aged >55 years in southern sub-Saharan Africa. In sharp contrast, China achieved a 78.2% reduction in age-standardized DALY rates during the same period. These divergent trajectories highlight critical gaps in global health system performance and underscore the imperative for tailored, equitable public health strategies focused on comprehensive screening, chronic disease management, and reproductive health.

Indexed as

DALYsdisability-adjusted life yearsglobal disease burdenhealth disparitiespediatricsthalassemias

Identifiers

PMID42633131
PMCPMC13499138

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.