Dual-gene regulation of NGF overexpression and P75NTR knockdown enhances BMSC osteogenesis by suppressing pyroptosis.

Ying Ji, Zheng Lv, Ye Wang, Yongkang Mao, Honghu Lin, Jianjia Huang, Hoan Nguyen Quoc, Chaoyong Bei

Abstract read

In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ying JiTrauma Orthopedics Department, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541001, China.

Zheng LvDepartment of Nuclear Medicine, Fourth Hospital of Harbin Medical University, Harbin, Heilongiiang 150001, China.

Ye WangFifth Clinical Medical College, Guilin Medical University, Guilin, Guangxi 541002, China.

Yongkang MaoTrauma Orthopedics Department, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541001, China.

Honghu LinTrauma Orthopedics Department, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541001, China.

Jianjia HuangTrauma Orthopedics Department, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541001, China.

Hoan Nguyen QuocTrauma Orthopedics Department, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541001, China.

Chaoyong BeiTrauma Orthopedics Department, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone defects present a major clinical challenge in regenerative medicine, where bone marrow mesenchymal stem cells (BMSCs) are widely used but often show limited osteogenic efficacy. In this study, we developed an engineered tissue strategy combining lentivirus-mediated dual-gene regulation and an allogeneic bone scaffold to enhance bone regeneration. BMSCs were modified to overexpress nerve growth factor (NGF) and knock down the p75 neurotrophin receptor (P75NTR), and their effects on osteogenesis and pyroptosis were evaluated

Indexed as

bone defect healingbone marrow mesenchymal stem cellsbone tissue engineeringdual-gene deliveryengineered biomaterialspyroptosis regulation

Identifiers

PMID42633095

DOI10.1016/j.isci.2026.116979

PMCPMC13498978

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.