Evidence map›Paper›PMID 42633087›Full record

ArticleIBRO neuroscience reports2026

Network pharmacology, molecular docking and

Bruno Dupon Akamba Ambamba, Messanga Me Ngo'o Jonathan, Akono Fama Yves Marc, Nyabissick Mondjiep Sandrine, Njayou Mbouangouore Ingrid Reine, Ngarchindi Emmanuel, Nkodo Abega Laurent, Njanjo Ejanmoua Merveille La Blonde, Ebogo Enyegue Françoise Alexandra, Fils Armand Ella and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IBRO neuroscience reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Bruno Dupon Akamba AmbambaDepartment of Biochemistry, Faculty of Science, University of Yaounde 1, Yaounde P.O. Box 812, Cameroon.
Messanga Me Ngo'o JonathanDepartment of Biochemistry, Faculty of Science, University of Yaounde 1, Yaounde P.O. Box 812, Cameroon.
Akono Fama Yves MarcDepartment of Biochemistry, Faculty of Science, University of Yaounde 1, Yaounde P.O. Box 812, Cameroon.
Nyabissick Mondjiep SandrineDepartment of Biochemistry, Faculty of Science, University of Yaounde 1, Yaounde P.O. Box 812, Cameroon.
Njayou Mbouangouore Ingrid ReineDepartment of Biochemistry, Faculty of Science, University of Yaounde 1, Yaounde P.O. Box 812, Cameroon.
Ngarchindi EmmanuelDepartment of Biochemistry, Faculty of Science, University of Yaounde 1, Yaounde P.O. Box 812, Cameroon.
Nkodo Abega LaurentDepartment of Biochemistry, Faculty of Science, University of Yaounde 1, Yaounde P.O. Box 812, Cameroon.
Njanjo Ejanmoua Merveille La BlondeDepartment of Biochemistry, Faculty of Science, University of Yaounde 1, Yaounde P.O. Box 812, Cameroon.
Ebogo Enyegue Françoise AlexandraDepartment of Biochemistry, Faculty of Science, University of Yaounde 1, Yaounde P.O. Box 812, Cameroon.
Fils Armand EllaDepartment of Biochemistry, Faculty of Science, University of Yaounde 1, Yaounde P.O. Box 812, Cameroon.
Damaris Enyegue MandobCenter of Nutrition and Functional Foods, Yaounde P.O. Box 8024, Cameroon.
Judith Laure NgondiDepartment of Biochemistry, Faculty of Science, University of Yaounde 1, Yaounde P.O. Box 812, Cameroon.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AD is a neurodegenerative disorder marked by progressive cognitive decline, particularly memory impairment, largely driven by cholinergic dysfunction. This study aimed to investigate the pharmacological basis and modes of action of the identified TT-TeMac™ compounds againsts cholinergic dysfunction associated with memory loss. TT-TeMac™ compounds targets which were identified by LC-MS were extracted from SwissTarget Prediction and PharmMapper, while cholinergic dysfunction-related targets were obtained from DisGeNET and GeneCards. Fifteen common targets were identified, with nine key targets highlighted by STRING, Cytoscape, and Venny analyses and confirmed by molecular docking using MOE. The

Indexed as

Cholinergic dysfunction and memory lossMolecular DockingNetwork pharmacologyTT-TeMac™

Identifiers

PMID42633087
PMCPMC13499058

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.