Evidence map›Paper›PMID 42633066›Full record

ArticleiScience2026

Space radiation promotes clonal hematopoiesis and hematologic disease upon aging in a driver gene and sex-specific manner.

Megan A Evans, Heather Doviak, Ariel H Polizio, Jesse D Cochran, Leslie R Kim, Eunbee Park, Mark C Thel, Christopher R Xie, Ajay R Srinivasan, Lucila Marino and 11 more

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Megan A EvansDivision of Cardiovascular Medicine, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Heather DoviakDivision of Cardiovascular Medicine, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Ariel H PolizioDivision of Cardiovascular Medicine, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Jesse D CochranDivision of Cardiovascular Medicine, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Leslie R KimDivision of Cardiovascular Medicine, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Eunbee ParkDivision of Cardiovascular Medicine, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Mark C ThelDivision of Cardiovascular Medicine, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Christopher R XieDivision of Cardiovascular Medicine, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Ajay R SrinivasanDivision of Cardiovascular Medicine, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Lucila MarinoDivision of Cardiovascular Medicine, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Yoshimitsu YuraDivision of Cardiovascular Medicine, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Hanna SunDivision of Cardiovascular Medicine, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Sahithi MikkilineniDivision of Cardiovascular Medicine, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Andrew J McKamyDivision of Cardiovascular Medicine, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
George PhilipposCambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Ana Filipa DominguesCambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
George S VassiliouCambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Samantha C St JeanDepartment of Pathology and Center for Comparative Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Eric M PietrasDivision of Hematology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
David A GoukassianCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Kenneth WalshDivision of Cardiovascular Medicine, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

Funding

Women's Oncology Program - WONP30CA044579 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Dina Gould Halme · 1987 to 2026
$72.1M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007267 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI GARCIA-BLANCO, MARIANO A. · 1985 to 2024
$13.4M
Mosaic loss of Y chromosome in blood and heart failureR01AG073249 · NIA · UNIVERSITY OF VIRGINIA · PI WALSH, KENNETH · 2021 to 2025
$2.6M
Aberrant glycolysis as a driver of mutant HSPC expansion in clonal hematopoiesisR01DK137183 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Eric M Pietras · 2023 to 2026
$1.8M
Mosaic Loss of the Y Chromosome in Cardiac AmyloidosisR01AG086508 · NIA · UNIVERSITY OF VIRGINIA · PI KENNETH WALSH · 2024 to 2026
$1.7M
The Profibrotic Effects of Hematopoietic Y Chromosome Loss in HFpEFR01AG092528 · NIA · UNIVERSITY OF VIRGINIA · PI KENNETH WALSH · 2026 to 2026
$689k
NCI NIH HHS P30 CA044579NIA NIH HHS R01 AG073249NIA NIH HHS R01 AG086508NIA NIH HHS R01 AG092528NIDDK NIH HHS R01 DK137183NIGMS NIH HHS T32 GM007267
6 · The paper itself

Abstract

The effects of space radiation on clonal hematopoiesis (CH) and its impact on long-term health outcomes are unknown. Using male and female murine models of

Indexed as

clonal hematopoiesisdriver genegenetic mutationhematologic diseaseradiationsexTP53

Identifiers

PMID42633066
PMCPMC13498954

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.