Evidence map›Paper›PMID 42632923›Full record

ArticleHGG advances2026

Variant harmonization critically determines polygenic score transferability for lipid traits in Samoan populations.

Toni-Ann J Yapp, Mohanraj Krishnan, Shuwei Liu, Samantha L Manna, Hong Cheng, Take Naseri, Muagututuʻa Sefuiva Reupena, Satupaʻitea Viali, John Tuitele, Ranjan Deka and 5 more

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Article in HGG advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Toni-Ann J YappDepartment of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: tjy19@pitt.edu.
Mohanraj KrishnanDepartment of Biobehavioral Health, Pennsylvania State University, State College, PA, USA.
Shuwei LiuDepartment of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
Samantha L MannaDepartment of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA; Center for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, University of Pittsburgh, Pittsburgh, PA, USA.
Hong ChengDepartment of Environmental & Public Health Sciences, University of Cincinnati, Cincinnati, OH, USA.
Take NaseriNaseri & Associates Public Health Consultancy Firm and Family Health Clinic, Apia, Samoa; Center for Global Public Health, School of Public Health, Brown University, Providence, RI, USA.
Muagututuʻa Sefuiva ReupenaLutia I Puava 'ae Mapu I Fagalele, Apia, Samoa.
Satupaʻitea VialiOceania University of Medicine, Apia, Samoa.
John TuiteleDepartment of Public Health, Government of American Samoa, Pago Pago, AS, USA.
Ranjan DekaDepartment of Environmental & Public Health Sciences, University of Cincinnati, Cincinnati, OH, USA.
Nicola L HawleyDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.
Stephen T McGarveyCenter for Global Public Health, School of Public Health, Brown University, Providence, RI, USA; Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA; Department of Anthropology, Brown University, Providence, RI, USA.
Daniel E WeeksDepartment of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA; Department of Biostatistics and Health Data Science, University of Pittsburgh, Pittsburgh, PA, USA.
Ryan L MinsterDepartment of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
Jenna C CarlsonDepartment of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA; Department of Biostatistics and Health Data Science, University of Pittsburgh, Pittsburgh, PA, USA.

Funding

Studies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
Integrated cellular, mouse and human research on a novel missense variant influencing adiposity in SamoansR01HL093093 · NHLBI · BROWN UNIVERSITY · PI MCGARVEY, STEPHEN T. · 2009 to 2019
$8.2M
Next Generation Association Studies of Adiposity in Samoans Enhanced by a Samoan-Specific Whole Genome Sequence Reference PanelR01HL133040 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Ryan Lee Minster · 2017 to 2026
$7.5M
GENOME SCAN FOR OBESITY SUSCEPTIBILITY LOCI IN SAMOANSR01DK059642 · NIDDK · BROWN UNIVERSITY · PI MCGARVEY, STEPHEN T. · 2000 to 2004
$2.6M
GENOME SCAN FOR NIDDM SUSCEPTIBILITY GENES AMONG SAMOANSR01DK055406 · NIDDK · UNIVERSITY OF CINCINNATI · PI DEKA, RANJAN · 1998 to 2002
$664k
GENETICS OF CVD RISK FACTORS IN SAMOANSR01HL052611 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAMBOH, M. ILYAS · 1995 to 1998
–
ADIPOSITY INSULIN ELECTROLYTES AND SAMOAN BLOOD PRESSURER01AG009375 · NIA · MIRIAM HOSPITAL · PI MCGARVEY, STEPHEN T. · 1990 to 1994
–
NHLBI NIH HHS HHSN268201100037CNHLBI NIH HHS HHSN268201500016CNHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS R01 HL052611NHLBI NIH HHS R01 HL093093NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL133040NIA NIH HHS R01 AG009375NIDDK NIH HHS R01 DK055406NIDDK NIH HHS R01 DK059642
6 · The paper itself

Abstract

Dyslipidemia is a significant risk factor for cardiovascular disease (CVD), the leading cause of death in Samoa. Polygenic scores (PGSs) for lipid traits offer promise for improved CVD risk prediction; however, their performance in Pacific Islander populations-comprising only 0.002% of genome-wide association study (GWAS) participants as of 2024-remains unknown. We evaluated the transferability of multi-ancestry PGS for LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), triglycerides (TGs), and total cholesterol (TC) in 4,342 Samoan adults across five cohorts spanning 1990-2010. PGSs from Graham et al. and Kanoni et al. multi-ancestry meta-analyses were harmonized with genome-wide imputed genotypes using a Samoan-specific reference panel, and performance was assessed via incremental R

Indexed as

cardiovascular diseasedyslipidemialipid traitsPacific Islanderspolygenic scoresSamoa

Identifiers

PMID42632923
PMCPMC13594622

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.