Evidence map›Paper›PMID 42632907›Full record

ReviewChemMedChem2026

Exploiting Multicomponent Reactions to Drive the Development of Novel Antitubercular Agents: An Overview.

Diogo Nunes, Rui Moreira, Maria de Jesus Perry, Francisca Lopes

Abstract readReview
In one paragraph

Review in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Diogo NunesResearch Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisboa, Portugal.ORCID https://orcid.org/0000-0003-1072-4451
Rui MoreiraResearch Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisboa, Portugal.ORCID https://orcid.org/0000-0003-0727-9852
Maria de Jesus PerryResearch Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisboa, Portugal.ORCID https://orcid.org/0000-0002-8110-2740
Francisca LopesResearch Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisboa, Portugal.ORCID https://orcid.org/0000-0002-5350-147X

Funding

Fundação para a Ciência e a Tecnologia https://doi.org/10.54499/2023.03653.BDFundação para a Ciência e a Tecnologia https://doi.org/10.54499/2023.17181.ICDTFundação para a Ciência e a Tecnologia https://doi.org/10.54499/UID/04138/2025
6 · The paper itself

Abstract

Tuberculosis (TB) remains a global epidemic, and Mycobacterium tuberculosis (Mtb), its etiological agent, continues to be the deadliest single infectious agent worldwide. Our inability to eradicate TB is strongly related to Mtb's ability to alternate between an active and latent disease state, and a lack of pharmacological agents that effectively target the heterogeneity of TB, which leads downstream to the emergence of drug resistance. The ongoing quest to discover novel effective chemical agents to improve anti-TB regimens remains a significant challenge. Multicomponent reactions (MCRs) have been shown to generate highly diverse chemical libraries in a time- and cost-efficient, sustainable manner, and thus have emerged as powerful tools to accelerate drug discovery and development. This review provides an overview of the chemical libraries of anti-TB agents developed by MCRs, highlighting the contributions of MCRs to advance anti-TB drug discovery through a medicinal chemistry approach.

Indexed as

Antitubercular AgentsDrug DiscoveryMycobacterium tuberculosisSmall Molecule LibrariesTuberculosisHumansMicrobial Sensitivity TestsMolecular StructureStructure-Activity RelationshipAntitubercular AgentsSmall Molecule Librariesdrug discoverymulticomponent reactionsM ycobacterium tuberculosistuberculosis

Identifiers

PMID42632907
PMCPMC13499889

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.