Evidence map›Paper›PMID 42632897›Full record

ArticleBMC complementary medicine and therapies2026

Insights on supplement use during cancer care from online Reddit conversations.

Barliz Waissengrin, Karen O'Connor, Celina H Shirazipour, Flores Amaro Ivan, Karen L Reckamp, Graciela Gonzalez-Hernandez, Jane C Figueiredo

Abstract read
In one paragraph

Article in BMC complementary medicine and therapies, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Barliz WaissengrinDepartment of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd Suite AC1072, Los Angeles, CA, 90048, USA.
Karen O'ConnorDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Celina H ShirazipourDepartment of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd Suite AC1072, Los Angeles, CA, 90048, USA.
Flores Amaro IvanDepartment of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Karen L ReckampDepartment of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd Suite AC1072, Los Angeles, CA, 90048, USA.
Graciela Gonzalez-Hernandez *David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Jane C Figueiredo *Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd Suite AC1072, Los Angeles, CA, 90048, USA. Jane.Figueiredo@cshs.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDietary supplement use is common among patients with cancer, yet limited data exist on how patients perceive and use these products during treatment. Traditional research methods may not fully capture patient-driven motivations and experiences. Social media platforms such as Reddit provide a unique opportunity to examine real-world, unfiltered discussions about supplement use in the oncology setting.

methodsPosts from the subreddit r/cancer published between November 2010 and December 2022 that referenced dietary supplement use were identified using natural language processing (NLP) techniques. A 10% random sample (n = 155) of the identified posts (n = 1,488) was analyzed qualitatively using directed content analysis. Posts were categorized by purpose (seeking vs. reporting use), intended use (treatment of cancer vs. symptom management), and supplement type (vitamin, mineral, other). Frequencies of themes related to supplement use, treatment goals, and decision-making motivations were assessed.

resultsAmong users who specified their cancer type, breast, lung, and colorectal cancers were most frequently mentioned. 59% of posts were inquiries about supplement use, and 41% described personal experiences. Intended use was evenly divided between symptom management (51%) and cancer treatment (49%). Vitamins were the most commonly mentioned supplement category (38%). Reported motivations included managing fatigue, nausea, pain, and emotional distress. Discussions frequently reflected attempts to identify supportive strategies outside of conventional medical care.

conclusionsReddit represents a valuable, underutilized resource for understanding cancer patients' perspectives on dietary supplement use. Insights derived from these online discussions highlight the importance of addressing supplement use in clinical encounters and underscore the need for further research to guide safe and effective integration of supplements into oncology care.

Indexed as

Dietary SupplementsNeoplasmsSocial MediaFemaleHumansMotivationCancerDietary SupplementsQualitative ResearchRedditSocial Media

Identifiers

PMID42632897
PMCPMC13499959

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.