Observational studyBMC anesthesiology2026
Tigecycline pharmacokinetics in critically ill patients receiving extracorporeal membrane oxygenation: a prospective multicentre pilot study.
Observational study in BMC anesthesiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
Funding
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Abstract
backgroundTigecycline is frequently used to treat multidrug-resistant infections in critically ill patients. However, its pharmacokinetics in patients receiving extracorporeal membrane oxygenation (ECMO) are poorly defined, raising concerns about the adequacy of standard dosing in this population.
methodsThis prospective, multicentre pilot study included adult ICU patients receiving venovenous (VV) or venoarterial (VA) ECMO and standard tigecycline dosing. Serial plasma samples were collected at steady state to determine tigecycline concentrations using liquid chromatography-tandem mass spectrometry. Pharmacokinetic parameters, including maximum plasma concentration (C
resultsFifteen patients were included (13 VV-ECMO, 2 VA-ECMO). Marked interindividual variability in tigecycline exposure was observed. Median C
conclusionTigecycline pharmacokinetics in ECMO-supported critically ill patients show high variability, with higher exposure in VA-ECMO than in VV-ECMO. Standard dosing may be insufficient, supporting therapeutic drug monitoring and further studies to inform individualized dosing strategies in this complex population.
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